中国现代医学杂志2026，Vol.36Issue(4)：35-42,8.DOI:10.3969/j.issn.1005-8982.2026.04.006
Nrf2信号通路在肝脏缺血再灌注损伤中的保护机制及治疗前景的研究进展
Research progress on the protective mechanisms and therapeutic prospects of the Nrf2 signaling pathway in hepatic ischemia-reperfusion injury
摘要
Abstract
Hepatic ischemia-reperfusion injury(HIRI)is a common and unavoidable complication following liver transplantation and hepatectomy.Its pathogenesis involves multiple pathophysiological processes,including oxidative stress,sterile inflammation,mitochondrial dysfunction,and apoptosis.Nuclear factor erythroid 2-related factor 2(Nrf2)is a key regulator of cellular antioxidant responses that maintains cellular redox balance by activating the expression of antioxidant factors such as heme oxygenase-1(HO-1),superoxide dismutase(SOD),and glutathione(GSH).Nrf2 also protects the liver by inhibiting the release of pro-inflammatory factors,regulating inflammatory signaling pathways,reducing inflammatory responses,and decreasing apoptosis.This review summarizes the mechanistic roles of Nrf2 in HIRI,recent advances in Nrf2 activators,and their prospects for clinical translation.Furthermore,it discusses the application potential of cutting-edge technologies such as artificial intelligence and organoid models in Nrf2-related research,aiming to provide a theoretical basis for the prevention and treatment of HIRI through targeting the Nrf2 signaling pathway.关键词
肝脏缺血再灌注损伤/Nrf2/抗氧化应激/抗炎/抗凋亡/Nrf2激活剂Key words
hepatic ischemia-reperfusion injury/Nrf2/antioxidant/anti-inflammatory/anti-apoptotic/Nrf2 activators分类
医药卫生引用本文复制引用
覃根,邓银芝..Nrf2信号通路在肝脏缺血再灌注损伤中的保护机制及治疗前景的研究进展[J].中国现代医学杂志,2026,36(4):35-42,8.基金项目
湖北省自然科学基金面上项目(No:2024AFB1027) （No:2024AFB1027）
