中国现代医学杂志2026，Vol.36Issue(4)：54-59,6.DOI:10.3969/j.issn.1005-8982.2026.04.009
丙泊酚-瑞芬太尼复合七氟醚在心脏外科手术中的麻醉效果研究
Anesthetic effects of propofol-remifentanil combined with sevoflurane in cardiac surgery
摘要
Abstract
Objective To evaluate the anesthetic effects of propofol-remifentanil combined with sevoflurane in cardiac surgery.Methods A total of 103 patients undergoing cardiac surgery from September 2022 to September 2024 at the 71st Army Group Hospital were enrolled and randomly assigned via a sealed envelope method to either the control group(n=51)or the combination group(n=52).In the control group,anesthesia was maintained with propofol and remifentanil.In the combination group,anesthesia was maintained with inhaled sevoflurane combined with propofol and remifentanil.General characteristics,intraoperative hemodynamic parameters,recovery indicators,postoperative Visual Analog Scale(VAS)scores,and adverse reactions were compared between the two groups.Results A comparison of MAP and HR between the combination group and the control group at T0,T1,T2,T3 demonstrated that they were different across the time points(P<0.05)and between the groups(P<0.05).The MAP in the combination group was higher than that in the control group at T1 and T2,while the HR was lower than that in the control group at T1,T2,T3.The change trend of MAP showed a statistically significant difference between the two groups(P<0.05),whereas the change trend of HR showed no statistically significant difference(P>0.05).The combination group had shorter times to spontaneous breathing recovery,extubation,eye opening,and verbal response compared with the control group(P<0.05).A comparison of VAS scores between the combination group and the control group at 2,4,and 6 hours postoperatively indicated that they were different across the time points(P<0.05)and between the groups(P<0.05).The combination group had lower VAS scores,indicating relatively better analgesic efficacy.The change trend of the VAS scores differed between the two groups(P<0.05).There was no statistically significant difference in the overall incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of propofol-remifentanil with sevoflurane provides significant anesthetic effects in cardiac surgery.关键词
心脏外科手术/术中血流动力学/丙泊酚/瑞芬太尼/七氟醚Key words
cardiac surgery/intraoperative hemodynamics/propofol/remifentanil/sevoflurane分类
医药卫生引用本文复制引用
程俏,茆璐..丙泊酚-瑞芬太尼复合七氟醚在心脏外科手术中的麻醉效果研究[J].中国现代医学杂志,2026,36(4):54-59,6.基金项目
江苏省重点研发计划项目(No:BE2022049) （No:BE2022049）
