针灸临床杂志2026，Vol.42Issue(1)：7-11,5.DOI:10.19917/j.cnki.1005-0779.026002
基于"通督滋阳"理论探讨夹脊电针调控脊髓损伤"铁死亡-炎症反应"机制研究
Mechanisms of Jiaji EA Regulating Ferroptosis and Inflammatory Responses in Spinal Cord Injury Based on'Tongdu Ziyang'Theory
摘要
Abstract
Jiaji electro-acupuncture(EA)can promote motor function recovery after spinal cord injury by modulating mechanisms such as neuronal autophagy,oxidative stress,ferroptosis,and inflammatory responses in the damaged area.Studies have shown that Jiaji EA specifically regulates the ferroptosis Xc-/GPX4 pathway,increasing the expression of ferroptosis-related factors GSH and GPX4,thereby inhibiting neuronal death and protecting neuron survival.Additionally,it affects HMGB1 levels,suppressing activation of NLRP3 inflammasome.This mechanism aligns with TCM theory of'Tongdu Ziyang',which emphasizes harmonizing Yin and Yang.Acupoint selection along Du meridian and Bladder meridian can mobilize Yang energy throughout the body to facilitate recovery.With further research into the theoretical basis of EA for spinal cord injury,molecular biology studies are increasingly validating its multi-target effects,providing a modern medical interpretation of'Tongdu Ziyang'theory.关键词
脊髓损伤/夹脊穴/电针/铁死亡/炎症反应/通督滋阳Key words
Spinal cord injury/Jiaji acupoints/Electro-acupuncture/Ferroptosis/Inflammatory response/Tongdu Ziyang分类
医药卫生引用本文复制引用
栾逸先,朱荟一,孙忠人,柯维华,王丽娟,伊思锐,朱嘉民,田洪昭..基于"通督滋阳"理论探讨夹脊电针调控脊髓损伤"铁死亡-炎症反应"机制研究[J].针灸临床杂志,2026,42(1):7-11,5.基金项目
国家自然科学基金面上项目,编号:81873378 （）
首批海南省"南海新星"科医疗卫生人才平台项目,编号:NHXX-WJW-2023018 （）
黑龙江省中医药管理局中医药科研课题,编号:ZHY2022-120、ZHY2024-231 （）
黑龙江中医药大学青年科技创新能力培养计划,编号:2024XJJ-QNCX024. （）
