中国中医骨伤科杂志2026，Vol.34Issue(2)：58-63,6.DOI:10.20085/j.cnki.issn1005-0205.260209
牛膝温经汤治疗寒湿痹阻型膝骨关节炎的临床研究
Clinical Study on Niuxi Wenjing Decoction in the Treatment of Knee Osteoarthritis with Cold-Dampness Obstruction Syndrome
摘要
Abstract
Objective:To discuss the clinical efficacy of Niuxi Wenjing decoction in the treatment of knee osteoarthritis(KOA)with cold-dampness obstruction syndrome.Methods:Eighty patients with KOA and cold-dampness obstruction were randomly divided into observation group and control group with 40 cases in each group by using random number table method.The control group received oral celecoxib capsules,0.2 g each times,twice daily,whereas the observation group was given oral Niuxi Wenjing decoction,1 dose per day,taken warmly twice a day.Both treatments were given for 4 weeks.The changes in VAS scores,TCM symptom scores,WOMAC scores,musculoskeletal ultrasound assessments,and serum levels of IL-1β and TNF-α were observed before and after treatment.Results:No statistically significant differences were observed in any of observation indicators between the two groups before treatment(P>0.05).After treatment,sig-nificant decreases were found in all observation indicators within each group compared to their respective baseline levels(P<0.01).Compared with the control group,the observation group showed lower scores after treatment for both TCM syndrome assessment and WOMAC scores(P<0.01).Conclusion:Niuxi Wenjing decoction shows significant efficacy in the treatment of KOA with cold-dampness obstruction.The mechanism may be associated with the reduction of inflamma-tory factors(IL-1β,TNF-α).关键词
膝骨关节炎/牛膝温经汤/寒湿痹阻Key words
knee osteoarthritis/Niuxi Wenjing decoction/cold-dampness obstruction分类
医药卫生引用本文复制引用
鲁俊山,房彩平,高竟,陶帅..牛膝温经汤治疗寒湿痹阻型膝骨关节炎的临床研究[J].中国中医骨伤科杂志,2026,34(2):58-63,6.基金项目
江苏省中医药科技发展计划面上项目(MS2023149)泰州市大健康产业创新能力提升(社会发展)非企项目(TS202313)泰州市中医药科技项目(TZ202306) （MS2023149）
