中国中医骨伤科杂志2026，Vol.34Issue(2)：64-68,5.DOI:10.20085/j.cnki.issn1005-0205.260210
加味五子衍宗丸治疗脾肾阳虚型骨质疏松症的临床疗效观察
Clinical Efficacy Observation of the Modified Wuzi Yanzong Pills in Treating Osteoporosis with Yang Deficiency of Spleen and Kidney
摘要
Abstract
Objective:To evaluate the clinical efficacy of the modified Wuzi Yanzong pills in treating of osteoporosis with Yang deficiency of the spleen and kidney pattern.Methods:The clinical data of 58 patients with osteoporosis of Yang defi-ciency of the spleen and kidney from January 2024 to January 2025,were retrospectively analyzed.These patients were di-vided into control group of 26 cases and observation group with 32 cases according to the different treatment modalities.The control group was treated with calcitriol and calcium,and the observation group was treated with modified Wuzi Yanzong pills decoction(Polygonati Rhizoma 24 g,Cuscutae Semen 24 g,Lycii Fructus 24 g,Rubi Fructus 12 g,Schisandrae Sphenantherae Fructus 6 g,Plantaginis Semen 6 g,Sparganii Rhizoma 15 g,Curcumae Rhizoma 15 g.This formula warms and tonifies the spleen and kidneys while promoting blood circulation and resolving stasis)combined with calcitriol and calcium carbonate D3 tablets.The results of pain VAS score,clinical symptoms scores,bone mineral density(BMD),bone markers,TCM syndrome score were compared between the two groups.Results:After 6 months of treatment,the pain VAS score,clinical symptoms score,and TCM syndrome score in the observation group were all lower than those in the control group.Additionally,the observation group showed an increase in PINP level and a decrease in β-CTX level(P<0.05).However,there was no increase in BMD in the observation group(P>0.05),while the BMD in the control group decreased compared with that before treatment(P<0.05).Conclusion:Modified Wuzi Yanzong pills can relieve bone pain in patients with osteoporosis due to Yang deficiency of the spleen and kidney and maintain BMD levels,the underlying mechanism may be related to regulating the activity of osteoblasts and osteoclasts.关键词
加味五子衍宗丸/骨质疏松症/骨密度/脾肾阳虚型/骨代谢标志物Key words
modified Wuzi Yanzong pills/osteoporosis/bone mineral density/Yang deficiency of spleen and kidney/bone metabolic markers分类
医药卫生引用本文复制引用
李扬,石龙,陈龙,章轶立,张志文..加味五子衍宗丸治疗脾肾阳虚型骨质疏松症的临床疗效观察[J].中国中医骨伤科杂志,2026,34(2):64-68,5.基金项目
湖北省重点研发计划项目(2024BCB035) （2024BCB035）
