中药材2025，Vol.48Issue(8)：1963-1966,4.DOI:10.13863/j.issn1001-4454.2025.08.016
小花八角果实中1个新的苯并呋喃型木脂素及神经保护活性
A New Benzofuranoid Neolignan from the Fruits of Illicium micranthum and the Neuroprotective Activities
摘要
Abstract
Objective:To investigate the chemical constituents from the fruits of Illicium micranthum and their neuroprotective ac-tivities.Methods:The 95%ethanol extract from the fruits of Illicium micranthum was isolated and purified by using MCI-gel,silica gel column chromatography,and semi-preparative HPLC.The structures were identified by using techniques such as NMR and MS.The neu-roprotective activities of these compounds were assessed by using the corticosterone(CORT)-induced PC12 cell damage model.Results:Four compounds were isolated from the fruits of Illicium micranthum and identified as illicranthin A(1),spathulatol(2),icariside E4(3),isolariciresinol(4),respectively.Conclusion:Among them,compound 1 is a new compound,compounds 2 to 4 are isolated from Il-licium micranthum for the first time.Compounds 1 and 2 can inhibit CORT-induced PC12 cell injury and have weak neuroprotective ac-tivities.关键词
小花八角/化学成分/神经保护活性Key words
Illicium micranthum Dunn/Chemical constituents/Neuroprotective activities分类
医药卫生引用本文复制引用
雷铁,赵秋叶,李珍全,殷世焕,周慧玲,吴兴德,丁林芬..小花八角果实中1个新的苯并呋喃型木脂素及神经保护活性[J].中药材,2025,48(8):1963-1966,4.基金项目
云南省基础研究计划面上项目(202301AT070266) （202301AT070266）
