中国医科大学学报2026，Vol.55Issue(2)：97-102,6.DOI:10.12007/j.issn.0258-4646.2026.02.001
细胞间通信异常在子痫前期发病机制中的作用
Role of aberrant intercellular communication in preeclampsia pathogenesis
摘要
Abstract
Preeclampsia(PE)is a pregnancy-specific multisystem disorder with a global incidence of approximately 2%to 8%,remaining a leading cause of maternal and perinatal morbidity and mortality.The characteristic pathological PE features include placental ischemia,endothelial dysfunction,and systemic inflammation.However,prevailing hypotheses,such as abnormal trophoblast invasion and immune dysregulation,do not fully account for PE-related clinical heterogeneity and multiorgan involvement.Recently,intercellular communication network disruption has become increasingly recognized as a central driving mechanism of pathophysiological PE progres-sion.In this study,we systematically summarized the aberrant mechanisms of various intercellular communication modes in PE,including paracrine signaling,extracellular vesicles,gap junctions,and immunological synapses.Moreover,we discussed emerging diagnostic and therapeutic strategies for targeting these pathways.In this study,we aimed to provide new perspectives for elucidating PE pathogenesis and for developing precise interventions.关键词
子痫前期/细胞间通信/疾病预测/治疗策略Key words
preeclampsia/intercellular communication/disease prediction/therapeutic strategy分类
医药卫生引用本文复制引用
陈炳南,乔宠..细胞间通信异常在子痫前期发病机制中的作用[J].中国医科大学学报,2026,55(2):97-102,6.基金项目
国家重点研发计划(2023YFC2705900) （2023YFC2705900）
国家自然科学基金(81370735,81771610) （81370735,81771610）
辽宁省民生科技计划联合计划(2021JH2/10300123) （2021JH2/10300123）
沈阳市科技计划(20-205-4-004) （20-205-4-004）
兴辽英才计划(XLYC2005008) （XLYC2005008）
