摘要
Abstract
Objective:To evaluate the clinical efficacy of fiberoptic bronchoscopy-guided sputum suction combined with bronchoalveolar lavage in patients with chronic obstructive pulmonary disease(COPD)complicated by severe pneumonia,and to investigate its effects on serum inflammatory markers,pulmonary function,and clinical symptoms.Method:A total of 80 patients with COPD complicated by severe pneumonia who were admitted to Suyang Hospital of Traditional Chinese Medicine between January 2023 and December 2024 were enrolled and randomly assigned into two groups,with 40 patients in each group.The study group received bronchoscopic sputum suction combined with bronchoalveolar lavage,while the control group received conventional treatment including anti-infective therapy,oxygen supplementation,and expectorant therapy.Serum levels of C-reactive protein(CRP),procalcitonin(PCT),and interleukin-6(IL-6),as well as pulmonary function indices[forced expiratory volume in one second(FEV1),percentage of predicted FEV1(FEV1%pred),and maximal mid-expiratory flow(MEF25%～75%)]were measured before and after treatment in both groups.In addition,the time to improvement of clinical symptoms and length of hospital stay were recorded.Result:After treatment,serum CRP,PCT,and IL-6 levels in the study group were significantly lower than those in the control group,with statistically significant difference(P<0.05).Pulmonary function indices(FEV1,FEV1%pred,and MEF25%～75%)showed significant improvement compared with baseline,with greater improvements observed in the study group than in the control group,with statistically significant difference(P<0.05).The length of hospital stay and time to symptom relief were shorter in the study group,with a statistically significant difference(P<0.05).The total effective rate was significantly higher than that of the control group,with a statistically significant difference(P<0.05).Conclusion:In patients with COPD complicated by severe pneumonia,bronchoscopic sputum suction combined with bronchoalveolar lavage can help alleviate airway pathological changes,reduce the inflammatory burden,improve pulmonary function,and exert a positive impact on clinical outcomes.关键词
慢性阻塞性肺疾病/重症肺炎/纤维支气管镜/肺泡灌洗/炎性因子/肺功能Key words
Chronic obstructive pulmonary disease/Severe pneumonia/Fiberoptic bronchoscopy/Alveolar lavage/Inflammatory factors/Pulmonary function
