中国医科大学学报2026，Vol.55Issue(2)：171-175,5.DOI:10.12007/j.issn.0258-4646.2026.02.013
乳酸及乳酸化修饰在皮肤创面愈合中的研究进展
Research progress on lactate and lactylation modification in skin wound healing
摘要
Abstract
Wound healing involves multiple stages,including hemostasis,inflammation,proliferation,and remodeling.Previous studies have confirmed that lactate accelerates wound repair by regulating immune responses and promoting cell proliferation,while recent research has revealed its roles in activating key gene expression through lactylation(an epigenetic modification)and synergistically opti-mizing wound repair via metabolic reprogramming.This article focuses on the mechanisms underlying the regulatory functions of lactate and lactylation in the wound-healing process,exploring their potential to promote tissue repair through metabolic reprogramming and epi-genetic modification,and provides a new perspective for developing therapeutic strategies targeted at metabolic-epigenetic networks.关键词
乳酸/乳酸化修饰/创面愈合/皮肤/代谢重编程Key words
lactic acid/lactilation/wound healing/skin/metabolic reprogramming分类
医药卫生引用本文复制引用
谭驰宇,张悦,张旖骁,王哲..乳酸及乳酸化修饰在皮肤创面愈合中的研究进展[J].中国医科大学学报,2026,55(2):171-175,5.基金项目
国家自然科学基金(82473232) （82473232）
辽宁省科学技术计划(2023JH2/20200095,2023JH2/101700170) （2023JH2/20200095,2023JH2/101700170）
