中药材2025，Vol.48Issue(9)：2254-2262,9.DOI:10.13863/j.issn1001-4454.2025.09.020
基于LC-MS/MS技术的四妙汤水煎液及入血成分分析
Analysis of Simiao Decoction and Absorbed Compounds in the Blood Based on LC-MS/MS
摘要
Abstract
Objective:To analyze the decoction and the absorbed compounds in the blood of Simiao Decoction based on the serum drug chemistry method.Methods:LC-MS/MS was used to detect the prototype and metabolic components in the decoction and rat ser-um,and their metabolic pathways were analyzed.Results:114 core comparative components were obtained from Simiao Decoction;148 core comparative components were obtained from blank serum;The serum containing Simiao Decoction obtained 158 core comparative components.Conclusion:It has been preliminarily determined that components such as 7α-hydroxycholesterol,taurocholic acid,glyco-cholic acid,and 3α,7α-dihydroxy-5β-cholic acid may be the material basis for the pharmacological effects of Simiao Decoction when it enters the bloodstream,and bile acid metabolism may be the main metabolic pathway for Simiao Decoction entering the bloodstream.关键词
四妙汤/含药血清/入血成分/化学成分/LC-MSKey words
Simiao Decoction/Drug-containing serum/Absorbed compounds in the blood/Chemical constituents/LC-MS分类
医药卫生引用本文复制引用
李倩,陈雨佳,范志梁,葛少明,柴艺汇,管连城,陈云志..基于LC-MS/MS技术的四妙汤水煎液及入血成分分析[J].中药材,2025,48(9):2254-2262,9.基金项目
国家自然科学基金项目(82260890) （82260890）
