针灸推拿医学（英文版）2026，Vol.24Issue(1)：24-30,7.DOI:10.1007/s11726-026-1549-x
针药并用治疗脑卒中后血管性痴呆的疗效及对血清IL-6和SOD的影响
Efficacy of combined acupuncture and traditional Chinese herbs in the treatment of poststroke vascular dementia and the effects on serum IL-6 and SOD
摘要
Abstract
Objective:To observe the efficacy of acupuncture combined with traditional Chinese herbs in the treatment of poststroke vascular dementia(VD)and the effects on serum interleukin(IL)-6 and superoxide dismutase(SOD). Methods:A total of 240 patients with poststroke VD were selected and randomly divided into two groups according to the random number table method,with 120 cases in each group.Both groups received Hua Tan Tong Luo(phlegm-resolving and collateral-activating)formula,once daily;the observation group was additionally treated with Yi Shen Tiao Du(kidney-tonifying and Governor Vessel-regulating)acupuncture once daily for 6 consecutive days,followed by 1 d of rest.Both groups were treated for 15 d as one course,for a total of 2 courses.After treatment,the total effective rate was compared.Changes in scores of traditional Chinese medicine(TCM)symptoms,clinical dementia rating(CDR),National Institutes of Health stroke scale(NIHSS),and Chinese version of mini-mental state examination(MMSE),and serum levels of IL-6 and SOD were observed in both groups. Results:The total effective rate in the observation group was higher than that in the control group(P<0.05).After treatment,TCM symptom,CDR,and NIHSS scores,and serum IL-6 levels in both groups were lower than those before treatment(P<0.05),while MMSE scores and serum SOD levels were higher than those before treatment(P<0.05).After treatment,the observation group showed lower TCM symptom,CDR,and NIHSS scores,and serum IL-6 levels than the control group(P<0.05),and higher MMSE scores and serum SOD levels than the control group(P<0.05). Conclusion:Compared to Hua Tan Tong Luo formula alone,Yi Shen Tiao Du acupuncture combined with Hua Tan Tong Luo formula demonstrates better efficacy in reducing dementia severity,improving cognitive and neurological function,and inhibiting inflammation in patients with poststroke VD.关键词
针刺疗法/针药并用/中风/中风后遗症/痴呆,血管性/认知障碍/痰瘀阻络证/随机对照试验Key words
Acupuncture Therapy/Acupuncture Medication Combined/Stroke/Poststroke Syndrome/Dementia,Vascular/Cognitive Dysfunction/Phlegm and Blood Stasis Obstructing Collaterals Pattern/Randomized Controlled Trial分类
医药卫生引用本文复制引用
柳娜,周媛,孔谐和..针药并用治疗脑卒中后血管性痴呆的疗效及对血清IL-6和SOD的影响[J].针灸推拿医学（英文版）,2026,24(1):24-30,7.基金项目
This study was supported by the Research Cultivation Project of Beijing Municipal Hospital(北京市属医院科研培育课题,No.PZ2022015). （北京市属医院科研培育课题,No.PZ2022015）
