中国卒中杂志2026，Vol.21Issue(1)：105-112,8.DOI:10.3969/j.issn.1673-5765.2026.01.012
基于神经递质图谱的卒中后抑郁患者个体化诊疗探索——2例病例报道
Exploring Individualized Diagnosis and Treatment for Post-Stroke Depression Based on Neurotransmitter Atlas:A Report of Two Cases
摘要
Abstract
Post-stroke depression(PSD)patients often exhibit significantly reduced 5-hydroxytryptamine(5-HT)levels.This alteration is closely associated with stroke-induced disruption of neural pathways and metabolic abnormalities.Serotonin-selective reuptake inhibitors(SSRIs),such as sertraline,the first-line antidepressant drugs,selectively inhibit presynaptic 5-HT reuptake,thereby increasing synaptic 5-HT concentrations.This case report describes two cases of ischemic PSD.Using molecular imaging techniques,the stroke lesions and affected nuclei were mapped onto 5-HT receptor/transporter density atlases,and accordingly identified presynaptic and postsynaptic injury subtypes.The results showed that the two patients presented with presynaptic injury and postsynaptic injury,respectively,suggesting that different PSD subtypes may exhibit differential response to sertraline in antidepressant treatment.This case report provides novel insights for developing precise diagnostic subtypes and individualized treatment strategies for PSD.关键词
缺血性卒中/卒中后抑郁/神经递质映射/分子影像学/病例报道Key words
Ischemic stroke/Post-stroke depression/Neurotransmitter mapping/Molecular imaging/Case report分类
医药卫生引用本文复制引用
张之婕,张华,卫景沛,钱勋琦,赵子珺..基于神经递质图谱的卒中后抑郁患者个体化诊疗探索——2例病例报道[J].中国卒中杂志,2026,21(1):105-112,8.基金项目
中央高水平中医医院临床科研业务费资助(DZMG-QNHB009) （DZMG-QNHB009）
