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Integrative Analysis of scRNA-Seq and Bulk RNA-SeqReveals Novel Transcription Factor Regulating Endothelial Heterogeneity Induced by Lrg1 Following Cerebral Ischemia-Reperfusion

Shaofeng Xiong Wenkai Lv Guosheng Cao Longsheng Fu WenLiu Mengfan Lei Yanni Lv

BIOCELL2026，Vol.50Issue(1)：P.248-272,25.

BIOCELL2026，Vol.50Issue(1)：P.248-272,25.DOI:10.32604/biocell.2025.073401

Integrative Analysis of scRNA-Seq and Bulk RNA-SeqReveals Novel Transcription Factor Regulating Endothelial Heterogeneity Induced by Lrg1 Following Cerebral Ischemia-Reperfusion

Shaofeng Xiong ¹Wenkai Lv ²Guosheng Cao ³Longsheng Fu ⁴WenLiu ²Mengfan Lei ⁴Yanni Lv⁵

作者信息

1. Department of pharmacy,The First Affiliated Hospital,Jiangxi Medical College,Nanchang University,Nanchang,330006,China School of Pharmacy,Jiangxi Medical College,Nanchang University,Nanchang,330036,China
2. Institute of Chinese Materia Medica,Jiangxi Provincial Institute of Traditional Chinese Medicine,Nanchang,330077,China
3. College of Pharmacy,Hubei University of Chinese Medicine,Wuhan,430000,China
4. Department of pharmacy,The First Affiliated Hospital,Jiangxi Medical College,Nanchang University,Nanchang,330006,China
5. Department of pharmacy,The First Affiliated Hospital,Jiangxi Medical College,Nanchang University,Nanchang,330006,China Key Laboratory of Rare Neurological Diseases of Jiangxi Provincial Health Commission,The First Affiliated Hospital,Jiangxi Medical College,Nanchang University,Nanchang,330036,China
折叠

摘要

关键词

Single-cell RNA sequencing/endothelial heterogeneity/leucine-rich alpha-2 glycoprotein 1/zinc finger MIZ-type containing 1 Protein/Frizzled 3/transcription factor/cerebral ischemia reperfusion

分类

医药卫生

引用本文复制引用

Shaofeng Xiong,Wenkai Lv,Guosheng Cao,Longsheng Fu,WenLiu,Mengfan Lei,Yanni Lv..Integrative Analysis of scRNA-Seq and Bulk RNA-SeqReveals Novel Transcription Factor Regulating Endothelial Heterogeneity Induced by Lrg1 Following Cerebral Ischemia-Reperfusion[J].BIOCELL,2026,50(1):P.248-272,25.

基金项目

supported by the Foundation Project:National Natural Science.Foundation of China(Nos.:82460249,82100417,81760094) （Nos.:82460249,82100417,81760094）

The Foundation of Jiangxi Provincial Department of Science and Technology Outstanding Youth Fund Project(20212BAB206022,20242BAB23080). （20212BAB206022,20242BAB23080）

BIOCELL

ISSN：0327-9545

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