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Blood serum from individuals with Alzheimer’s disease alters microglial phagocytosis in vitro

Barbara Altendorfer Rodolphe Poupardin Sophie Lefèvre-Arbogast Claudine Manach Dorrain Y.Low Mireia Urpi-Sarda Cristina Andres-Lacueva Raúl González-Domínguez Thomas K.Felder Julia Tevini Marco Zattoni Andreas Koller Reinhold Schmidt Paul J.Lucassen Silvie R.Ruigrok Chiara de Lucia Andrea Du Preez Catherine Helmer Jeanne Neuffer Cécile Proust-Lima Aniko Korosi Cécilia Samieri Sandrine Thuret Ludwig Aigner

Neural Regeneration Research2026，Vol.21Issue(6)：P.2433-2439,7.
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Neural Regeneration Research2026，Vol.21Issue(6)：P.2433-2439,7.DOI:10.4103/NRR.NRR-D-24-01287

Blood serum from individuals with Alzheimer’s disease alters microglial phagocytosis in vitro

Barbara Altendorfer 1Rodolphe Poupardin 2Sophie Lefèvre-Arbogast 3Claudine Manach 4Dorrain Y.Low 4Mireia Urpi-Sarda 5Cristina Andres-Lacueva 5Raúl González-Domínguez 5Thomas K.Felder 6Julia Tevini 7Marco Zattoni 1Andreas Koller 8Reinhold Schmidt 9Paul J.Lucassen 10Silvie R.Ruigrok 11Chiara de Lucia 12Andrea Du Preez 12Catherine Helmer 3Jeanne Neuffer 3Cécile Proust-Lima 3Aniko Korosi 10Cécilia Samieri 3Sandrine Thuret 13Ludwig Aigner14

作者信息

  • 1. Institute of Molecular Regenerative Medicine,Paracelsus Medical University,Salzburg,Austria
  • 2. Experimental and Clinical Cell Therapy Institute,Paracelsus Medical University,Salzburg,Austria
  • 3. University of Bordeaux,Inserm,Bordeaux Population Health Research Center,Bordeaux,France
  • 4. UniversitéClermont Auvergne,INRAE,UMR1019,Human Nutrition Unit,Clermont Ferrand,France
  • 5. Nutrition,Food Science and Gastronomy Department,Faculty of Pharmacy and Food Science,Nutrition and Food Safety Research Institute(INSA),CIBER Fragilidad y Envejecimiento Saludable(CIBERFES),Instituto de Salud Carlos Ⅲ,University of Barcelona,Barcelona,Spain
  • 6. Department of Laboratory Medicine,Paracelsus Medical University,Salzburg,Austria Institute of Pharmacy,Paracelsus Medical University,Salzburg,Austria
  • 7. Department of Laboratory Medicine,Paracelsus Medical University,Salzburg,Austria
  • 8. Research Program for Experimental Ophthalmology and Glaucoma Research,Department of Ophthalmology and Optometry,University Hospital of the Paracelsus Medical University,Salzburg,Austria
  • 9. Department of Neurology,Medical University of Graz,Graz,Austria
  • 10. Brain Plasticity Group,Swammerdam Institute for Life Sciences,Center for Neuroscience,University of Amsterdam,Amsterdam,Netherlands
  • 11. Brain Plasticity Group,Swammerdam Institute for Life Sciences,Center for Neuroscience,University of Amsterdam,Amsterdam,Netherlands École Polytechnique Fédérale de Lausanne-Brain Mind Institute-Laboratory of Behavioral Genetics,Lausanne,Switzerland
  • 12. Department of Basic and Clinical Neuroscience,Maurice Wohl Clinical Neuroscience Institute,Institute of Psychiatry,Psychology and Neuroscience,King’s College London,London,UK
  • 13. Department of Basic and Clinical Neuroscience,Maurice Wohl Clinical Neuroscience Institute,Institute of Psychiatry,Psychology and Neuroscience,King’s College London,London,UK Department of Neurology,University Hospital Carl Gustav Carus,Technische Universität Dresden,Dresden,Germany
  • 14. Institute of Molecular Regenerative Medicine,Paracelsus Medical University,Salzburg,Austria Austrian Cluster of Tissue Regeneration,Vienna,Austria
  • 折叠

摘要

关键词

Alzheimer’s disease/blood serum/eicosapentaenoic acid/in vitro parabiosis/metabolome/microglia/omega-3 fatty acids/phagocytosis

分类

医药卫生

引用本文复制引用

Barbara Altendorfer,Rodolphe Poupardin,Sophie Lefèvre-Arbogast,Claudine Manach,Dorrain Y.Low,Mireia Urpi-Sarda,Cristina Andres-Lacueva,Raúl González-Domínguez,Thomas K.Felder,Julia Tevini,Marco Zattoni,Andreas Koller,Reinhold Schmidt,Paul J.Lucassen,Silvie R.Ruigrok,Chiara de Lucia,Andrea Du Preez,Catherine Helmer,Jeanne Neuffer,Cécile Proust-Lima,Aniko Korosi,Cécilia Samieri,Sandrine Thuret,Ludwig Aigner..Blood serum from individuals with Alzheimer’s disease alters microglial phagocytosis in vitro[J].Neural Regeneration Research,2026,21(6):P.2433-2439,7.

基金项目

part of the EU consortium DCogPlast‘Diet Cognition and Plasticity”funded by the Joint Programming Initiative“A Health Diet for a Healthy Life”(JPI-HDHL)via the BMWFW(BMWFW-10.420/0009-WF/V/3c/2015 and the Medical Research Council UK:MR/N030087/1)(to LA and ST) （JPI-HDHL）

Further,LA was supported by the PMU-FFF ResearchFund(A-16/01/019-AIG)and BA by the PMU-Research and Innovation Fund(PMU-RIF)(project 2023-PRE-008-Altendorfer) （A-16/01/019-AIG）

PJL was supported by the Center for Urban Mental Health,and AK and PJL by Alzheimer Nederland and the ZonMW Program Mechanisms Of DEMentia(MODEM)and by the Gravitation program iCNS of the Dutch Research Council(NWO) （MODEM）

CAL was supported by Grant PID2020-114921RB-C21,Maria de Maeztu Unit of Excellence grant CEX2021-001234-M funded by MCIU/AEI/and CIBERFES,CB16/10/00269,from the Instituto de Salud Carlos III all of them by“ERDF A way of making Europe”,the Generalitat de Catalunya’s Agency AGAUR of2021SGR00687 and ICREA Award. （）

Neural Regeneration Research

1673-5374

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