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CD4^(+)T cells in cancer:dual roles,exhaustion,and therapeutic breakthroughs

Yangyang Zhang Jingli Xu Siwei Pan Yuqi Wang Qianyu Zhao Ziyang Huang Can Hu Xiangdong Cheng

Cancer Biology & Medicine2026，Vol.23Issue(1)：P.42-59,18.

Cancer Biology & Medicine2026，Vol.23Issue(1)：P.42-59,18.DOI:10.20892/j.issn.2095-3941.2025.0414

CD4^(+)T cells in cancer:dual roles,exhaustion,and therapeutic breakthroughs

Yangyang Zhang ¹Jingli Xu ²Siwei Pan ²Yuqi Wang ²Qianyu Zhao ²Ziyang Huang ¹Can Hu ²Xiangdong Cheng²

作者信息

1. College of Pharmaceutical Sciences,Zhejiang University of Technology,Hangzhou 310014,China Department of Gastric Surgery,Zhejiang Cancer Hospital,Hangzhou 310014,China Hangzhou Institute of Medicine(HIM),Chinese Academy of Sciences,Hangzhou 310014,China Zhejiang Key Laboratory of Prevention,Diagnosis and Therapy for Gastrointestinal Cancer,Hangzhou 310014,China Zhejiang Provincial Research Center for Upper Gastrointestinal Tract Cancer,Zhejiang Cancer Hospital,Hangzhou 310014,China
2. Department of Gastric Surgery,Zhejiang Cancer Hospital,Hangzhou 310014,China Hangzhou Institute of Medicine(HIM),Chinese Academy of Sciences,Hangzhou 310014,China Zhejiang Key Laboratory of Prevention,Diagnosis and Therapy for Gastrointestinal Cancer,Hangzhou 310014,China Zhejiang Provincial Research Center for Upper Gastrointestinal Tract Cancer,Zhejiang Cancer Hospital,Hangzhou 310014,China
折叠

摘要

关键词

Mechanism of differentiation/dual role/T cell exhaustion/immunotherapeutic strategies/translational clinical applications

分类

医药卫生

引用本文复制引用

Yangyang Zhang,Jingli Xu,Siwei Pan,Yuqi Wang,Qianyu Zhao,Ziyang Huang,Can Hu,Xiangdong Cheng..CD4^(+)T cells in cancer:dual roles,exhaustion,and therapeutic breakthroughs[J].Cancer Biology & Medicine,2026,23(1):P.42-59,18.

基金项目

supported by The National Key Research and Development Program of China(Grant No.2021YFA0910100) （Grant No.2021YFA0910100）

Healthy Zhejiang One Million People Cohort(Grant No.K-20230085) （Grant No.K-20230085）

supported by National Natural Science Foundation of China(Grant Nos.82304946 and 82573745) （Grant Nos.82304946 and 82573745）

Post-doctoral Innovative Talent Support Program(Grant No.BX2023375) （Grant No.BX2023375）

567 Foundation of Zhejiang Province(Grant No.LMS25H160006) （Grant No.LMS25H160006）

supported by the National Natural Science Foundation of China(Grant No.82473489) （Grant No.82473489）

the Medical Science and Technology Project of Zhejiang Province(Grant No.WKJ-ZJ-2202) （Grant No.WKJ-ZJ-2202）

the Natural Science Foundation of Zhejiang Province(Grant No.LBD24H290001) （Grant No.LBD24H290001）

supported by the National Natural Science Foundation of China(Grant No.82403546). （Grant No.82403546）

Cancer Biology & Medicine

ISSN：2095-3941

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