陆军军医大学学报2026，Vol.48Issue(4)：387-393,7.DOI:10.16016/j.2097-0927.202512040
人工智能重塑疫苗研发新范式:效率革命与精准设计
Artificial intelligence reshaping vaccine development:a new paradigm of efficiency revolution and precision design
摘要
Abstract
Artificial intelligence(AI)is systematically reshaping the entire vaccine research and development pipeline through integrating deep learning architectures with multi-omics data.This facilitates a paradigm shift from traditional trial-and-error empirical approaches to a novel rational design framework centered on data-driven and algorithm-generated methodologies.Despite challenges including data heterogeneity,model opacity,algorithmic bias,and lagging regulatory frameworks,AI enables a transformative leap from structural mimicry to functional innovation in vaccine design via deep integration with immunological mechanisms.This review comprehensively analyzes AI applications across key vaccine development stages:target identification,antigen design,adjuvant screening,process optimization,clinical trial design,and vaccine hesitancy mitigation.We particularly summarize recent tools,core architectures,functional features,and representative cases for AI-powered rational vaccine design,providing actionable references for future AI implementation in vaccinology.关键词
人工智能/深度学习/疫苗/佐剂Key words
artificial intelligence/deep learning/vaccine/adjuvants分类
医药卫生引用本文复制引用
顾江,李宇航..人工智能重塑疫苗研发新范式:效率革命与精准设计[J].陆军军医大学学报,2026,48(4):387-393,7.基金项目
Supported by the National Key Research and Development Program of China(2024YFC2310801)and the Projoet of Higher Education Teaching Reform Research of Chongqing(233584). 国家重点研发计划(2024YFC2310801) （2024YFC2310801）
重庆市高等教育教学改革研究项目(233584) （233584）
