海南医科大学学报2026，Vol.32Issue(3)：217-222,6.DOI:10.13210/j.cnki.jhmu.20250313.002
Th1/Th2、Th17/Treg失衡与儿童激素耐药型肾病综合征的相关性分析
Correlation between Th1/Th2,Th17/Treg imbalance and steroid-resistant nephrotic syndrome in children
摘要
Abstract
Objective:To investigate Helper T cells(Th)1/Th2,Th17/regulatory T cells(Treg).Association between Treg imbalance and steroid resistant nephrotic syndrome(SRNS)in children.Methods:A total of 142 children with primary ne-phrotic syndrome were recruited and were given glucocorticoid therapy for 4 weeks.The children were classified into steroid-sensitive nephrotic syndrome(SSNS)according to treatment response.SSNS 31 cases(SSNS group)and SRNS 111 cas-es(SRNS group).Another 53 healthy children were selected as control group.Th1/Th2 and Th17/Treg in peripheral blood were detected.The correlation factors affecting SRNS and the value of Th1/Th2 and Th17/Treg in diagnosing SRNS were analyzed.Results:The levels of Th2,Th17 and Th17/Treg in peripheral blood of SRNS and SSNS groups were higher than those of con-trol group(P<0.05),SRNS group was higher than that of SSNS group(P<0.05),and Th1,Treg and Th1/Th2 ratios of SRNS and SSNS groups were lower than those of control group(P<0.05).The SRNS group was lower than the SSNS group(P<0.05).Microscopic hematuria,urinary protein and Th17/Treg were risk factors for SRNS(P<0.05),and Th1/Th2 were pro-tective factors(P<0.05).Combined Th1/Th2 and Th17/Treg diagnosed that the area under the curve of SRNS was 0.831,which was higher than that of Th1/Th2 and Th17/Treg alone(P<0.05).Conclusion:The decrease of Th1/Th2 and the in-crease of Th17/Treg in peripheral blood of children with SRNS are related to the occurrence of SRNS,and are potential biomark-ers for the diagnose of SRNS.关键词
原发性肾病综合征/激素耐药型肾病综合征/免疫/辅助性T细胞/调节性T细胞/儿童Key words
Primary nephrotic syndrome/Steroid-resistant nephrotic syndrome/Immune/T helper cells/Regulatory T cells/Children分类
医药卫生引用本文复制引用
廖赵妹,梁振明,徐莉,蔡思铭..Th1/Th2、Th17/Treg失衡与儿童激素耐药型肾病综合征的相关性分析[J].海南医科大学学报,2026,32(3):217-222,6.基金项目
This study was supported by the Hainan Province Health Industry Research Project(22A200262) 海南省卫生健康行业科研项目(22A200262) （22A200262）
