海南医科大学学报2026，Vol.32Issue(4)：299-309,11.DOI:10.13210/j.cnki.jhmu.20250208.002
基于孟德尔随机化探究组织蛋白酶与急、慢性牙周炎的因果关联
Exploring the causal association between cathepsin and acute and chronic periodontitis based on Mendelian randomization
摘要
Abstract
Objective:To explore the clear causal association between 9 types of cathepsin(CTS)and acute periodontitis(AP)and chronic periodontitis(CP)using Mendelian randomization(MR).Methods:Genome-wide association studies(GWAS)data related to 9 CTSs and GWAS data of AP and CP populations were used for two-way MR analysis and multivariate MR analysis.The two-way causal relationship between the 9 CTSs and AP and CP was systematically explored by using inverse variance weighting(IVW)as the main method,and the independent causal effect CTS of the 9 CTSs on AP and CP were deter-mined by multivariate MR analysis.Results:In the forward MR analysis,the IVW results showed that there was a significant neg-ative correlation between CTSO and AP[OR(95%CI)=0.478(0.253-0.901),P=0.022].The results of reverse MR analysis showed that there was a significant negative correlation between AP and CTSF[OR(95%CI)=0.987(0.979-0.996),P=0.005].There was a significant positive correlation between CP and CTSG[OR(95%CI)=1.027(1.000-1.055),P=0.046]and CTSS[OR(95%CI)=1.035(1.002-1.069),P=0.037].The results of multivariate MR analysis showed that there was a negative corre-lation between CTSG and AP[OR(95%CI)=0.493(0.282-0.861),P=0.013].There was a positive correlation between CTSS and AP[OR(95%CI)=1.449(1.012-2.074),P=0.042].Conclusion:CTS plays a regulatory role in the development of AP and CP,which provides a new idea for the relationship between CTS and AP and CP,and provides new clues for its pre-vention and treatment.关键词
急性牙周炎/慢性牙周炎/组织蛋白酶/孟德尔随机化Key words
Acute periodontitis/Chronic periodontitis/Cathepsin/Mendelian randomization分类
医药卫生引用本文复制引用
刘双环,傅亚婷,黄佳惠,马潇,刘华..基于孟德尔随机化探究组织蛋白酶与急、慢性牙周炎的因果关联[J].海南医科大学学报,2026,32(4):299-309,11.基金项目
This study was supported by the Research Project of Xinjiang Second Medical College(ZR202406) （ZR202406）
the 2024 Autonomous Region Health and Wellness Research Special Project(BL202456) （BL202456）
Urumqi Traditional Chinese Medicine Science and Technology Innovation Project(ZYYMS-10) 新疆第二医学院科研项目(ZR202406) （ZYYMS-10）
2024年度自治区卫生健康保健科研专项项目(BL202456) （BL202456）
乌鲁木齐市中医药科技创新项目(ZYYMS-10) （ZYYMS-10）
