海南医科大学学报2026，Vol.32Issue(4)：310-320,11.DOI:10.13210/j.cnki.jhmu.20250708.003
鬼箭羽及其有效成分治疗糖尿病肾病作用机制研究进展
Research progress on the mechanism of Euonymus alatus and its active components in the treatment of diabetic kidney disease
摘要
Abstract
Diabetic kidney disease(DKD)is one of the most severe and prevalent microvascular complications of diabetes mellitus.Its incidence is increasing annually,posing a serious threat to human health.Euonymus alatus,a traditional Chinese me-dicinal herb known for its effects in promoting blood circulation and dredging collaterals,breaking blood stasis and resolving mass-es,as well as detoxifying and killing parasites,is highly consistent with the pathogenesis of kidney collateral stasis in DKD.Mod-ern pharmacological studies indicate that Euonymus alatus is rich in various bioactive components,including flavonoids,triterpe-noids,and alkaloids.Its therapeutic mechanism against DKD exhibits multi-target and multi-pathway regulatory characteristics:it improves insulin resistance by activating the peroxisome proliferator-activated receptor-γ(PPAR-γ)pathway;maintains lipid met-abolic homeostasis by regulating adipocytokines tumor necrosis factor-α(TNF-α)and adiponectin(ADPN);exerts antioxidant ef-fects by clearing reactive oxygen species(ROS)through activation of the nuclear factor erythroid 2-related factor 2(Nrf2)/antiox-idant response element(ARE)pathway,while reducing the release of pro-inflammatory factors such as TNF-α and interleukin-6(IL-6)via inhibition of the nuclear factor-κB(NF-κB)pathway;concurrently,it downregulates the transforming growth factor-β1(TGF-β1)/Sma-and Mad-related proteins(Smads)signaling axis to inhibit extracellular matrix deposition and delay renal fibro-sis.This article systematically reviews the relevant active components of Euonymus alatus in DKD treatment reported in domestic and international literature,and elucidates its mechanisms of action in-depth by integrating modern pharmacological research find-ings,for the purpose of providing a scientific foundation for the further development of Euonymus alatus and its in-depth research in DKD therapy.关键词
鬼箭羽/糖尿病肾病/消渴病肾病/作用机制Key words
Euonymus alatus/Diabetic kidney disease/Consumptive thirst involving kidney/Mechanisms分类
医药卫生引用本文复制引用
李云萍,张坤,王志刚,杨霞,李建军,于丹丹,温青青..鬼箭羽及其有效成分治疗糖尿病肾病作用机制研究进展[J].海南医科大学学报,2026,32(4):310-320,11.基金项目
This study was supported by the Natural Science Foundation Project of Gansu Province(25JRRE013) （25JRRE013）
High-Level Key Research Project Funded by Gansu Provincial Administration of Traditional Chinese Medicine(GZKZ-2024-39) （GZKZ-2024-39）
Key Project of University-Institution Collaborative Innovation Program(HXLH-XTCX15) 甘肃省自然科学基金(25JRRE013)、甘肃省中医药管理局高水平重点课题资助项目(GZKZ-2024-39)、院校协同创新项目重点项目(HXLH-XTCX15) （HXLH-XTCX15）
