菌物学报2026，Vol.45Issue(2)：1-9,9.DOI:10.13346/j.mycosystema.250107
真菌耐药机制中的染色体非整倍体现象研究进展
Research progress on chromosomal aneuploidy in the mechanism of fungal drug-resistance
摘要
Abstract
Fungal drug-resistance poses a serious threat to global public health,with mechanisms encompassing genetic mutations,epigenetic regulation,and genomic instability.Chromosomal aneuploidy has recently emerged as a critical driver of resistance.This review comprehensively summarizes the molecular mechanisms by which aneuploidy mediates resistance in pathogenic fungi,including gene dosage effects,transcriptional dysregulation,and metabolic pathway interference.Key findings reveal that Candida albicans upregulates efflux pump genes(CDR1/2)through chromosomal duplication,while Aspergillus fumigatus reduces azole susceptibility via cyp51A copy number amplification.In Cryptococcus neoformans,stress-induced aneuploidy exhibits dynamic plasticity,rapidly emerging under drug pressure and reverting upon withdrawal.Technologies such as whole genome sequencing(WGS)and qPCR have proven pivotal to be for clinical resistance prediction and therapeutic monitoring,yet cost and technical barriers hinder their widespread implementation.Future research should focus on deciphering the interplay between aneuploidy,epigenetic modifications,and mutational accumulation,alongside developing therapeutic strategies to correct aneuploidy and optimize rapid diagnostics for precision of medicine application.By synthesizing cross-species evidence,this review advances our understanding of fungal resistance mechanisms and informs the development of novel interventions.关键词
真菌耐药性/染色体非整倍体/基因组不稳定性/耐药机制/烟曲霉Key words
fungal resistance/chromosomal aneuploidy/genomic instability/resistance mechanism/Aspergillus fumigatus引用本文复制引用
钱晶晶,王晓东..真菌耐药机制中的染色体非整倍体现象研究进展[J].菌物学报,2026,45(2):1-9,9.基金项目
新疆维吾尔自治区天山英才医疗卫生中青年骨干高层次人才培养计划(TSYC202301B029) （TSYC202301B029）
新疆维吾尔自治区自然科学杰出青年基金(2021D01E30) This work was supported by the Xinjiang Uygur Autonomous Region Tianshan Talent Medical and Health Care High-level Talent Training Program for Young and Middle-aged Key Talents(TSYC202301B029)and the Xinjiang Uygur Autonomous Region Natural Science Foundation for Outstanding Youth(2021D01E30). （2021D01E30）
