中草药2026，Vol.57Issue(5)：1603-1609,7.DOI:10.7501/j.issn.0253-2670.2026.05.002
骆驼刺醋酸乙酯部位的化学成分研究
Chemical constituents of ethyl acetate extract from Alhagi sparsifolia
摘要
Abstract
Objective To study the chemical constituents from the ethyl acetate extract of Alhagi sparsifolia Shap.Methods The compounds were isolated and purified by silica gel,Sephadex LH-20,ODS column chromatography,and semi-preparative HPLC,and their structures were identified by modern spectroscopic techniques.The anti-cervical cancer activities of the compounds against human HeLa cells were evaluated by the MTT assay.Results Fifteen compounds were isolated from the ethyl acetate extract of A.sparsifolia and identified as 1-{1-[4-(4-hydroxyphenethoxy)phenethyl]-1H-pyrrol-2-l}ethan-1-one(1),5,7-dihydroxy-6-methoxyflavone(2),callyspongidipeptide A(3),cyclo-(D-proline-D-valine)(4),7-O-ethylguaiacyl glycerol(5),7-O-ethylguaiacyl glycerol(6),isololiolide(7),N-phenethylacetamide(8),skullcapflavone Ⅱ(9),4-hydroxyphenethyl alcohol(10),N-phenethylformamide(11),3'-methoxydaidzein(12),cyclo(alanine-proline)(13),N-(p-hydroxyphenethyl)formamide(14),and N-acetyltyramine(15).Conclusions Compound 1 is a new compound and named as alhagipyrrolizidine A.Compounds 1,5 and 6 showed significant activity against human HeLa cells,with IC50 values of 31.4,26.6 and 37.3 μmol/L,respectively.关键词
骆驼刺吡咯碱A/宫颈癌/骆驼刺/骆驼刺吡咯碱A/7-O-乙基愈创木基甘油/7-O-乙基愈创木基甘油/黄芩新素ⅡKey words
alhagipyrrolizidine A/cervical cancer/Alhagi sparsifolia Shap./alhagipyrrolizidine A/7-O-ethylguaiacyl glycerol/7-O-ethylguaiacyl glycerol/skullcapflavone Ⅱ分类
医药卫生引用本文复制引用
高艺玮,石磊岭,孙宇,卿德刚,宋海龙,韩莉莉..骆驼刺醋酸乙酯部位的化学成分研究[J].中草药,2026,57(5):1603-1609,7.基金项目
新疆维吾尔自治区重点研发计划项目(2022B03018-4) （2022B03018-4）
