中草药2026，Vol.57Issue(5)：1691-1702,12.DOI:10.7501/j.issn.0253-2670.2026.05.010
羧甲基淀粉钠与交联聚维酮对中药提取物共喷雾干燥复合粒子结构、表面自由能与关键直压性能的影响差异
Different effects of carboxymethyl starch sodium and polyvinylpyrrolidone on structure,free surface energy,and key direct compression properties of composite particle prepared by co-spray drying based on traditional Chinese medicine extracts
摘要
Abstract
Objective To investigate the different effects of carboxymethyl starch sodium(CMS)and polyvinylpyrrolidone(PVPP)on the structure,free surface energy,and key direct compression properties of composite particles produced by co-spray drying based on traditional Chinese medicines(TCM)extracts.Methods This study selected extracts of Fuling(Poria),Danggui(Angelicae Sinensis Radix),Huangqi(Astragali Radix),Danshen(Salviae Miltiorrhizae Radix et Rhizoma),and Jinyinhua(Lonicerae Japonicae Flos)(PC、AS、AM、SM、LJ)as model drugs,and CMS and PVPP as modifiers.The composite particles of TCM extracts(CP-PC/AS/AM/SM/LJ-CMS and CP-PC/AS/AM/SM/LJ-PVPP)were prepared via co-spray drying.The properties of the co-spray dring liquid,and structure,free surface energy and direct compression properties of composite particles were comprehensively characterized.The different effects of CMS and PVPP on these properties were analyzed by statistical analysis.Results The application of different modifiers led to differential variations in the properties of the co-spray dring liquid,as well as in the structural characteristics,free surface energy,and direct compression properties of the composite particles.Compared to PVPP,co-spray dried liquid containing CMS exhibited increased solid content and viscosity,and lower surface tension and hydrodynamic size(except for CP-SM/LJ-CMS);All composite particles exhibited spherical structures,and those containing CMS showed smoother surfaces and larger particle size than those containing PVPP;The composite particles containing CMS brightness values(except for CP-AM-CMS),hardness(except for CP-AS/AM-CMS),elasticity,and rebound property(except for CP-AS/AM-CMS)were lower;The cohesion(except for CP-PC/LJ-CMS),cohesion work(except for CP-SM/LJ-CMS),free surface energy(except for CP-SM/LJ-CMS),and polarity index(except for CP-SM-CMS)of composite particles containing CMS were relatively high;The Carr's index,Hausner ratio,angle of repose(except for CP-SM-CMS),and disintegration time(except for CP-LJ-CMS)of composite particles containing CMS were all smaller,while composite particles containing PVPP demonstrated higher tensile strength.Conclusion The properties of TCM extract co-spray drying solutions,structures,free surface energy,and direct compression performance of composite particles containing CMS and PVPP were exhibited different effects.These findings provide valuable insights for advancing co-spray drying technology in TCM extracts and for preparing composite particles suitable for direct powder compression.关键词
共喷雾干燥/复合粒子/羧甲基淀粉钠/交联聚维酮/结构/表面自由能/粉末直压Key words
co-spray drying/composite particles/carboxymethyl starch sodium/polyvinylpyrrolidone/structure/free surface energy/direct compression of powder分类
医药卫生引用本文复制引用
李哲,颜丹晨,明良山,温爱玲,方双翠,朱卫丰,钟志坚,管咏梅,吴文婷,关志宇,袁名艺..羧甲基淀粉钠与交联聚维酮对中药提取物共喷雾干燥复合粒子结构、表面自由能与关键直压性能的影响差异[J].中草药,2026,57(5):1691-1702,12.基金项目
江西省自然科学基金资助项目(20232ACB216015) （20232ACB216015）
赣鄱俊才支持计划·青年科技托举人才(2025QT07) （2025QT07）
