中国实用口腔科杂志2026，Vol.19Issue(1)：1-9,9.DOI:10.19538/j.kq.2026.01.001
光生物调节疗法靶向调控放射性口腔黏膜炎的微环境机制
Photobiomodulation therapy in radiation-induced oral mucositis:microenvironmental targets and regulatory mechanisms
摘要
Abstract
Radiation-induced oral mucositis(RIOM)is one of the most common complications in patients receiving ra-diotherapy for head and neck cancers,with an incidence re-ported as high as 80％-100％.RIOM is characterized by mu-cosal congestion,erosion,and ulceration,often accompanied by severe pain,dysphagia,or secondary infection.These symp-toms markedly impair patients' quality of life and significantly increase the risk of treatment interruption and healthcare bur-den.Currently,pharmacological management provides limited benefit and is frequently constrained by drug resistance and medication-related adverse effects.Photobiomodulation(PBM),a non-invasive physical therapy,has been recom-mended by multiple guidelines and expert consensuses for the prevention and management of RIOM.PBM delivers low-ener-gy visible or near-infrared light to the oral mucosa to modu-late cellular metabolism,attenuate inflammatory responses,and promote cell repair.However,the mechanisms by which PBM reshapes the pathological microenvironment of RIOM re-main to be fully elucidated.This review systematically de-scribes the multidimensional regulatory mechanisms of PBM in reshaping the unbalanced microenvironment of RIOM by modulating oxidative stress,inflammatory mediator and cell survival and repairing signals.The aim is to provide theoreti-cal support for the development of individualized PBM treat-ment strategies for RIOM.关键词
放射性口腔黏膜炎/光生物调节疗法/微环境调控/组织修复Key words
radiation-induced oral mucositis/photobio-modulation/microenvironment regulation/tissue repair分类
医药卫生引用本文复制引用
张帆,罗晶晶,周红梅..光生物调节疗法靶向调控放射性口腔黏膜炎的微环境机制[J].中国实用口腔科杂志,2026,19(1):1-9,9.基金项目
四大慢病重大专项(2023ZD0503000) （2023ZD0503000）
国家自然科学基金(82573832) （82573832）
四川省科技厅项目(2025ZNSFSC0548) （2025ZNSFSC0548）
天府锦城实验室(前沿医学中心)成果转化项目(2025ZH015) （前沿医学中心）
