中国实用口腔科杂志2026，Vol.19Issue(1)：10-18,26,10.DOI:10.19538/j.kq.2026.01.002
放射性口腔黏膜炎的小分子靶向药物研发
Development of small-molecule targeted drugs for radia-tion-induced oral mucositis
摘要
Abstract
Radiation-induced oral mucositis(RIOM)is a common and severe complication of radiotherapy for head and neck cancers.Its pathogenesis involves multiple processes,in-cluding oxidative stress,inflammatory response,immune acti-vation,and impaired epithelial repair.Currently,clinical inter-ventions for RIOM have limited efficacy,and there is a lack of specific therapeutic drugs targeting the underlying pathologi-cal mechanisms.In recent years,the intervention strategies for RIOM with small-molecule targeted drugs as the core have gradually become a research focus.This article systematically reviews small-molecule targeted drugs acting across various pathological stages of RIOM,including superoxide dismutase mimetics and nuclear factor erythroid 2-related factor 2(Nrf2)modulators that target oxidative stress,innate defense regula-tors that modulate innate immunity,nuclear factor κB(NF-κB)inhibitors that suppress key inflammatory pathway,and uridine phosphorylase inhibitors that promote mucosal epithe-lial repair,elaborating on their mechanisms of action,summa-rizing the preclinical and clinical research progress,and ana-lyzing key challenges in current drug development.Further-more,it looks forward to the future directions of development in multi-target combination therapies,aiming to provide theo-retical evidence and strategic support for the precise preven-tion and management of RIOM.关键词
放射性口腔黏膜炎/小分子靶向药物/氧化应激/炎症反应/临床试验Key words
radiation-induced oral mucositis/small-mol-ecule targeted drugs/oxidative stress/inflammatory response/clinical trials分类
医药卫生引用本文复制引用
蒋琴,周刚..放射性口腔黏膜炎的小分子靶向药物研发[J].中国实用口腔科杂志,2026,19(1):10-18,26,10.基金项目
四大慢病重大专项(2023ZD0503000) （2023ZD0503000）
