中国实用内科杂志2026，Vol.46Issue(2)：141-145,5.DOI:10.19538/j.nk2026020110
妊娠期特异性甲状腺功能参考值范围建议与分析
Recommendations and analysis of trimester-specific reference ranges for thyroid function
摘要
Abstract
Objective To establish trimester-specific reference ranges for thyroid function in pregnant women in the Shijiazhuang area,providing a basis for precise clinical evaluation and intervention.Methods A prospective longitudinal sequential study was conducted.A total of 120 women with singleton pregnancies(observation group)at the Second Hospital of Hebei Medical University from January 2022 to December 2023 were enrolled.Serum levels of thyroid-stimulating hormone(TSH),free thyroxine(FT4),free triiodothyronine(FT3),total thyroxine(TT4),and total triiodothyronine(TT3)were measured in the first,second,and third trimesters respectively.A concurrent control group consisting of 120 healthy non-pregnant women of childbearing age was recruited,and reference ranges were established.Results During pregnancy,TSH levels increased with gestational age(1.22,1.31,and 1.61 mU/L in the first,second,and third trimesters,respectively),while FT4 and FT3 levels decreased(FT4 was 15.62 pmol/L in the first trimester,declining to 12.15 pmol/L in the third trimester).The levels of TSH,FT4,and FT3 in all trimesters were significantly different from those in the control group(P＜0.05).TT4 and TT3 levels in each trimester in the observation group were higher than those in the control group(P＜0.05),with TT4 peaking in the second trimester.The upper limits of TSH reference ranges established in this study(3.80 mU/L in the first trimester,3.51 mU/L in the second trimester and 4.01 mU/L in the third trimester)were higher than those recommended by the ATA guidelines.Conclusion The trimester-specific reference ranges for thyroid function in the Shijiazhuang area exhibit significant regional specificity.Establishing localized reference ranges can reduce misdiagnosis and provide scientific support for the management of thyroid disorders during pregnancy.关键词
妊娠期特异性甲状腺功能/促甲状腺激素/纵向序贯研究Key words
trimester-specific thyroid function/thyroid-stimulating hormone/longitudinal sequential study分类
医药卫生引用本文复制引用
郝志华,常亚清,郑丽丽,辛虹,郝咏梅,张力辉,任明慧,黄静,李贵芝,李娜,赵雪,朱秋霄,刘静,郝慧瑶..妊娠期特异性甲状腺功能参考值范围建议与分析[J].中国实用内科杂志,2026,46(2):141-145,5.基金项目
河北省财政厅-政府资助临床医学优秀人才项目(冀财社[2019]139号) （冀财社[2019]139号）
