中国体外生命支持2026，Vol.24Issue(1)：35-40,6.DOI:10.13498/j.cnki.chin.j.ecls.2026.01.07
体外循环心脏瓣膜置换术后低蛋白血症相关危险因素与受试者工作特征曲线预测模型建立
Hypoproteinemia After Cardiac Valve Replacement With Cardiopulmonary Bypass Related Risk Factors and Receiver Operating Characteristic Curve Prediction Model Establishment
摘要
Abstract
Objective To investigate the risk factors associated with hypoproteinemia after cardiac valve replacement with cardiopulmonary bypass(CPB),and to establish a predictive model using receiver operating characteristic(ROC)curve analysis.Methods A total of 250 patients undergoing cardiac valve replacement under CPB in our hospital were enrolled.According to serum albumin(ALB)levels within 48 hours postoperatively,patients were divided into a hypoproteinemia group(n=65)and a non-hypoproteinemia group(n=185).Multivariate logistic regression was used to analyze risk factors,and ROC curve was applied to evaluate predictive performance and construct a predictive model.Results Multivariate logistic regression analysis revealed that advanced age(OR=1.037),female(OR=2.147),fatty liver disease(OR=4.402),prolonged lengthy CPB time(OR=1.016),extended postoperative cannulation(OR=1.182),pulmonary infection(OR=6.552),and gastrointestinal im-pairment(OR=3.957)were independent risk factors for hypoproteinemia following CPB cardiac valve replacement(P<0.05).ROC curve analysis demonstrated that the combined predictive model achieved an area under the curve(AUC)of 0.850(95%CI of 0.791-0.909),with a sensitivity of 0.846,and specificity of 0.762,indicating high predictive value.Conclusion Advanced age,female,fatty liver disease,prolonged CPB time,extended postoperative catheterization time,pulmonary infection and gas-trointestinal dysfunction are significant risk factors for hypoproteinemia after CPB cardiac valve replacement.关键词
体外循环/心脏瓣膜置换术/低蛋白血症/危险因素/防护/预测模型Key words
cardiopulmonary bypass/cardiac valve replacement/hypoproteinemia/risk factors/prevention/predictive modeling引用本文复制引用
郭恬,常琰,郭沙沙,金艳..体外循环心脏瓣膜置换术后低蛋白血症相关危险因素与受试者工作特征曲线预测模型建立[J].中国体外生命支持,2026,24(1):35-40,6.基金项目
空军军医大学第一附属医院2024年度学科助推计划(XJZT24LY40) （XJZT24LY40）
