中国中西医结合杂志2026，Vol.46Issue(2)：160-166,7.DOI:10.7661/j.cjim.20251112.306
雄激素性秃发湿热证中医量表研制
Development of Chinese Medicine Diagnosis Quantitative Scale of Androgenetic Alopecia Patients with Damp-Heat Syndrome
摘要
Abstract
Objective To preliminarily develop a quantitative scale for androgenetic alopecia(AGA)patients with damp-heat syndrome and to evaluate its performance,providing a reference for syndrome diagnosis of AGA.Methods Four diagnostic information was extracted through literature research and expert opinions to form an item pool.Clinical investigations were conducted in hospitals by assigning participants into a training group and a validation group.Four statistical methods—correlation coefficient method,Cronbach's alpha method,binary Logistic stepwise regression method,and systematic clustering—were used for item screening in the training group.Logistic regression analysis and factor analysis were applied for item weighting.The receiver operating characteristic(ROC)curve was used to determine the final diagnostic model,and Youden's index was calculated to identify the diagnostic threshold.The developed quantitative scale was tested and evaluated using the training and validation groups.Results A total of 280 AGA patients from(Hair Medical Center)National Center for Integrated Chinese and Western Medicine of China-Japan Friendship Hospital were enrolled and randomly assigned to a training group(210 cases)and a validation group(70 cases).After statistical item screening and weighting,the final quantitative scale score was calculated by Logistic regression analysis as:Scalp Oiliness × 5+Facial and Scalp Folliculitis × 7+Head Sweating × 5+High-Fat/High-Sugar Diet × 5+Bitter Taste in Mouth × 8+Sticky Stool ×7+Dark Urine × 7+Positive Fungal Microscopy × 22+Red Tongue × 13+Greasy Tongue Coating × 21.Symptom items were scored using a Likert 5-point scale(1～5 points),while other items(positive fungal microscopy,red tongue,greasy tongue coating)were scored using a binary scale(0 or 1 points).A total score of ≥ 118 was set as the diagnostic threshold for damp-heat syndrome.Evaluation results showed that Youden's indices were 0.85 and 0.79,and Kappa values were 0.85 and 0.78 in the training and validation groups,respectively.Conclusion The preliminarily developed Chinese medicine diagnostic quantitative scale for damp-heat syndrome in AGA demonstrated better diagnostic capability.关键词
中医诊断量化表/湿热证/雄激素性秃发Key words
Chinese Medicine Diagnostic Quantitative Scale/damp-heat syndrome/androgenetic alopecia引用本文复制引用
蒋宇琪,张丰川,王磊,刘青武,陈辉松,庄明月,杨顶权..雄激素性秃发湿热证中医量表研制[J].中国中西医结合杂志,2026,46(2):160-166,7.基金项目
中日友好医院高水平医院临床科研业务费资助项目(No.2023-NHLHCRF-YYPP-TS-06) （No.2023-NHLHCRF-YYPP-TS-06）
