组织工程与重建外科杂志2026，Vol.22Issue(1)：27-33,56,8.DOI:10.3969/j.issn.1673-0364.2026.01.003
单纯性皮罗序列征下颌骨三维形态的稠密对应分析
Dense correspondence analysis(DeCA)of 3D mandibular geometry in isolated Pierre Robin sequence
摘要
Abstract
Objective Isolated Pierre Robin sequence(Ⅰ-PRS)is caused by abnormal mandibular development,and traditional sparse landmark-based methods are insufficient to capture its complete 3D morphology.This study aimed to use dense correspondence-based 3D geometric morphometrics to precisely quantify mandibular features in Ⅰ-PRS and establish a morphological classification system.Methods This retrospective case-control study included CT data from 200 infants with Ⅰ-PRS and 31 normal infants.Mandibular models were generated through 3D reconstruction,and point-to-point registration was performed using dense correspondence analysis.Principal component analysis(PCA)was used to explore morphological variation within the Ⅰ-PRS group,followed by K-means clustering and canonical variate analysis(CVA)for subtype classification and validation.Results The Ⅰ-PRS mandible showed significant dysmorphology compared to normal controls,with the greatest variations found at the symphysis and mandibular angle.PCA and cluster analysis identified three stable morphotypes:Type I(short body,flat arch);Type Ⅱ(short ramus,V-shaped narrow arch,with posterior ramus rotation);and Type ⅡI(high-angle,flat arch).CVA confirmed the high statistical validity of this subtyping.Conclusion This study successfully quantified the morphological features of the Ⅰ-PRS mandible using dense correspondence analysis and,for the first time,identified and defined three objective morphological subtypes.This classification system provides an important morphological basis for understanding the clinical heterogeneity of Ⅰ-PRS and for guiding precision diagnosis and personalized surgical treatment.关键词
单纯性皮罗序列征/下颌骨/三维几何形态学/稠密对应分析/形态分型/主成分分析Key words
Isolated Pierre Robin sequence/Mandible/3D geometric morphometrics/Dense correspondence analysis/Morphological subtyping/Principal component analysis分类
医药卫生引用本文复制引用
陈亦阳,刘懿洁,刘佳玉,卢志远,吴彧,吴婉秋..单纯性皮罗序列征下颌骨三维形态的稠密对应分析[J].组织工程与重建外科杂志,2026,22(1):27-33,56,8.基金项目
广州地区临床高新、重大、特色技术项目(2023C-TS49). （2023C-TS49）
