福建中医药2026，Vol.57Issue(2)：16-22,7.DOI:10.13260/j.cnki.jfjtcm.2026.02004
基于序关系-熵权法和正交设计优选化浊散结除痹方水提工艺
Optimization of the Aqueous Extraction Process for Huazhuo Sanjie Chubi Decoction Based on G1-Entropy Weight Method and Orthogonal Design
摘要
Abstract
Objective:To optimize the aqueous extraction process of Huazhuo Sanjie Chubi Decoction using G1-entropy weight method combined with orthogonal design,providing a basis for its subsequent formulation development.Methods:The contents of phellodendrine hydrochloride,isofraxidin,astilbin,berberine hydrochloride,and rosmarinic acid in the extract were determined by high performance liquid chromatography(HPLC).A comprehensive score(Pj)was calculated based on the contents of these five components and the extraction rate using the G1-entropy weight method.With Pj as the evaluation index,an L9(34)orthogonal test was conducted to investigate the effects of extraction time,water addition,and extraction frequency,and to optimize the extrac‐tion process.Results:The optimal extraction conditions were determined as follows:adding 12-fold water,extracting 3 times for 2 h each.In verification tests under these conditions,the relative standard deviation(RSD)of Pj was 1.0%,and the extraction rate was>30%.Conclusion:The optimized extraction process is stable and feasible,providing a reference for the formulation research of Hua‐zhuo Sanjie Chubi Decoction.关键词
化浊散结除痹方/高效液相色谱/序关系-熵权法/正交设计/提取工艺Key words
Huazhuo Sanjie Chubi Decoction/high performance liquid chromatography/G1-entropy weight method/orthogo‐nal design/extraction process引用本文复制引用
郑卓铭,张婷,肖艳,张镇,林逸凡,黄鸣清,苏友新,陈鹏..基于序关系-熵权法和正交设计优选化浊散结除痹方水提工艺[J].福建中医药,2026,57(2):16-22,7.基金项目
国家重点研发计划"中医药现代化"重点专项(2022YFC3501200,2022YFC3501205) （2022YFC3501200,2022YFC3501205）
国家中医药管理局2021年岐黄学者支持项目(国中医药人教函[2022]6号) （国中医药人教函[2022]6号）
福建省省级财政专项(X2022008-财政专项) （X2022008-财政专项）
2023年技术创新重点攻关及产业化项目(2023XQ013) （2023XQ013）
福建中医药大学苏友新岐黄学者传承工作室项目(闽中医[2023]56号) （闽中医[2023]56号）
