口腔疾病防治2026，Vol.34Issue(3)：213-225,13.DOI:10.12016/j.issn.2096-1456.202550483
抗菌-再矿化-渗透协同策略治疗牙体硬组织疾病的研究进展
Research advances on a antibacterial-remineralization-infiltration synergistic strategy to treat dental hard tis-sue diseases
摘要
Abstract
This paper reviews research progress on a antibacterial-remineralization-infiltration synergistic strategy for the prevention and treatment of dental hard tissue diseases.Dental caries is a chronic infectious disease caused by cariogenic bacteria.Traditional fluoride prevention methods are unable to effectively halt the progression of deep caries due to limited antibacterial capacity and poor deep penetration.To address this,researchers have proposed an interrup-tion of dental caries strategy that integrates antibacterial,remineralization,and infiltration functions.This approach uti-lizes antibacterial components,such as metal ions,antibacterial peptides,and nanoparticles,to suppress cariogenic bac-terial activity.Bioactive glass and amorphous calcium phosphate materials induce in situ hydroxyapatite deposition to achieve dental hard tissue remineralization.Simultaneously,the materials penetrate deep into the micro-pores of a le-sion via high permeability,forming a physical barrier that blocks acid erosion and plaque re-invasion.This strategy is applicable not only for minimally invasive intervention in early caries but also extends to treating non-carious condi-tions,such as dentine hypersensitivity,wedge-shaped defect,and tooth erosion.Multiple in vitro and animal studies demonstrate that multifunctional coatings and nanocomposite systems developed under this systemic approach signifi-cantly enhance treatment efficacy for dental hard tissue diseases.Future advancements in biomimetic materials and smart delivery systems hold promise for achieving higher levels of structure-function reconstruction,which will propel dental hard tissue disease treatment toward precision,minimally invasive,and intelligent approaches.关键词
抗菌/再矿化/渗透性/金属离子/抗菌肽/纳米材料/生物活性玻璃/无定形磷酸钙/龋病/龋病阻断/牙本质敏感/楔状缺损/酸蚀症Key words
antibacterial/remineralization/infiltration/metal ions/antibacterial peptides/nanomaterials/bioactive glass/amorphous calcium phosphate/dental caries/interrupt dental caries/dentine hypersensitivity/wedge-shaped defect/dental erosion分类
医药卫生引用本文复制引用
张旭,杨庆祎..抗菌-再矿化-渗透协同策略治疗牙体硬组织疾病的研究进展[J].口腔疾病防治,2026,34(3):213-225,13.基金项目
国家重点研发计划(2022YFC2405900,2022YFC2405902) This study was supported by the grants from National Key R&D Program of China(No.2022YFC2405900,No.2022YFC2405902). （2022YFC2405900,2022YFC2405902）
