口腔疾病防治2026，Vol.34Issue(3)：273-280,8.DOI:10.12016/j.issn.2096-1456.202550529
腭部坏死性唾液腺化生1例及文献回顾
Necrotizing sialometaplasia of the palate:a case report and literature review
摘要
Abstract
Objective To enhance the recognition of necrotizing sialometaplasia(NS)by elucidating its clinical,pathological characteristics and key diagnostic points,providing a basis for the diagnosis and treatment of the disease.Methods This study has been reviewed and approved by the Medical Ethics Committee,and informed consent has been obtained from patients.Review the data of a patient with NS occurring at the junction of the right soft and hard palate,and comprehensively analyze its diagnostic process based on its clinical manifestations,imaging,and histopatho-logical examination results.And review the relevant literature on the disease.Results This study describes a 24-year-old male patient with a documented betel nut habit(2 pieces/day for>6 months),who presented with a bone-deep,ir-regular crateriform ulcer(3 mm×6 mm×5 mm)localized to the right hard-soft palate junction.Spiral CT showed a local soft tissue defect with no apparent underlying bone destruction.Histopathology demonstrated chronic inflammation of the mucosal and minor salivary gland tissues,with no evidence of malignancy.A final diagnosis of NS was estab-lished.The ulcer healed completely three weeks after initiation of local anti-inflammatory therapy.A literature review indicates that NS is a rare,benign salivary gland disorder,typically occurring at the hard-soft palate junction in middle-aged men(40-60 years).Its etiology remains unclear,but it is widely attributed to salivary lobe infarction following me-chanical trauma-induced ischemia.Due to its clinical resemblance to malignancy,it is often misdiagnosed.Treatment entails local anti-inflammatory measures and meticulous wound care aimed at promoting mucosal healing.Conclusion NS is a self-limiting,benign condition that poses a significant diagnostic challenge due to its close clinical simulation of malignancy.Thus,accurate diagnosis requires a combined assessment of clinical presentation,radiological features,and pathological findings.Treatment is predicated based on a conservative strategy with an emphasis on symptomatic man-agement.关键词
口腔黏膜病/坏死性唾液腺化生/溃疡/腭部/自限性/槟榔/组织病理/口腔恶性肿瘤Key words
oral mucosal diseases/necrotizing sialometaplasia/ulcer/palate/self-limiting/betel nut/his-topathology/oral malignant tumors分类
医药卫生引用本文复制引用
布向文,叶传进,储志娟,段宁,王翔,王文梅,彭巧..腭部坏死性唾液腺化生1例及文献回顾[J].口腔疾病防治,2026,34(3):273-280,8.基金项目
中国博士后科学基金项目(2023M741767) This study was supported by the grants from China Postdoctoral Science Foundation(No.2023M741767). （2023M741767）
