分析化学2026，Vol.54Issue(2)：171-182,中插1-中插2,14.DOI:10.19756/j.issn.0253-3820.251226
抑郁症的仪器检测技术及其研究进展
Development Progress of Instrumental Analysis Technologies for Detection of Depression
摘要
Abstract
Depression has become a universal public health challenge worldwide.Traditional diagnostic methods relying on clinical interviews and questionnaires often have strong subjectivity and lack clear biomarkers.In recent years,with the deepening understanding of the pathophysiological mechanisms of depression,accumulating evidence has demonstrated that depression is closely associated with alterations in specific biological indicators,including central neurotransmitters,peripheral inflammatory factors,and endogenous metabolic products,which may serve as potential biomarkers.These findings provide a solid theoretical foundation for the development of objective and quantitative precision diagnostic methods.Accordingly,a variety of detection technologies,including biomarker-based assays,have been actively explored for the objective diagnosis and auxiliary diagnosis of depression.These developments highlight the urgent clinical demand for diagnostic technologies that are rapid,objective,and highly accurate.Future research efforts therefore need to focus on the development of novel diagnostic technologies for depression which are rapid,sensitive,objective,and quantifiable.This paper systematically reviews the latest applications of chromatography,mass spectrometry,spectroscopy,electrochemical techniques,magnetic resonance imaging,and wearable sensor technologies in the screening and diagnosis of depression.It summarizes the potential biomarkers that may be useful for the precise diagnosis of depression,discusses the advantages and clinical applicability of each technology,and analyzes their future development trends and prospects.Notably,technologies such as mass spectrometry,particularly when integrated with multimodal detection approaches and artificial intelligence techniques,are expected to drive depression diagnostics toward more precise and non-invasive directions.Therefore,the future development of technologies and devices focusing on early screening,non-invasive detection,convenient diagnosis,and precise evaluation of depression is of great importance,as it will provide critical support for clinical intervention and prognosis improvement,and holds substantial academic value and translational clinical significance.关键词
抑郁症/仪器检测技术/生物标志物/多模态/研究进展/评述Key words
Depression/Instrumental detection technology/Biomarkers/Multimodality/Research progress/Review引用本文复制引用
隋华杰,郭雨虹,朱腾高,刘悦翔,方小伟,王国兵,陈焕文..抑郁症的仪器检测技术及其研究进展[J].分析化学,2026,54(2):171-182,中插1-中插2,14.基金项目
国家自然科学基金项目(No.22376084)、江西中医药大学校级科技创新团队发展项目(No.CXTD22005)、江西省科学技术厅管理科学项目(No.20252BAA100023)和济宁市重点研发计划项目(No.2024YXNS201)资助. Supported by the National Natural Science Foundation of China(No.22376084),the Jiangxi University of Chinese Medicine School-level Science and Technology Innovation Team Development Program(No.CXTD22005),the Management Science Project of Jiangxi Provincial Department of Science and Technology(No.20252BAA100023)and the Jining Key Research and Development Program(No.2024YXNS201). （No.22376084）
