甘肃中医药大学学报2026，Vol.43Issue(1)：27-40,14.DOI:10.16841/j.issn1003-8450.2026.01.05
菊花-茶防治高血压合并高脂血症最佳配比筛选及生物信息学作用机制研究
Screening of the optimal ratio of chrysanthemum-tea for prevention and treatment of hypertension complicated with hyperlipidemia and study on its bioinformatic mechanism
摘要
Abstract
Objective To investigate the relationship between the ratio of chrysanthemum-tea and its pharma-codynamic substance dissolution,as well as the mechanism of action in preventing and treating hypertension compli-cated with hyperlipidemia.Methods The content of main pharmacodynamic substances in different ratios of chry-santhemum-tea was determined by high-performance liquid chromatography(HPLC).Principal component analysis(PCA)was used to analyze the content of these substances.Active ingredients and targets of chrysanthemum-tea were retrieved from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCM-SP).Targets related to hypertension complicated with hyperlipidemia were obtained from GeneCards and UniProt databases,and common targets for chrysanthemum-tea intervention were identified.Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analyses were performed using the DAVID database,and results were validated by molecular docking technology.Results The highest dissolution of pharmacodynamic sub-stances was achieved at a chrysanthemum-tea ratio of 1∶3.The main active components included quercetin,luteo-lin,epigallocatechin gallate,and kaempferol.Core targets included protein kinase B(AKT1),mitogen-activated pro-tein kinase 1(MAPK1),tumor protein p53(TP53),and v-rel reticuloendotheliosis viral oncogene homolog A(RE-LA).GO and KEGG enrichment analyses indicated that the intervention primarily involved signaling pathways such as AGE-RAGE,interleukin(IL)-17,and tumor necrosis factor(TNF).Molecular docking results demonstrated strong binding affinity between the main active components and core targets.Conclusion The optimal ratio of chrysanthe-mum-tea for preventing and treating hypertension complicated with hyperlipidemia is 1∶3.The mechanism involves multiple components,targets,and pathways.关键词
高血压/高脂血症/菊花-茶/网络药理学/分子对接/高效液相色谱/主成分分析/机制研究Key words
hypertension/hyperlipidemia/chrysanthemum-tea/network pharmacology/molecular docking/high-performance liquid chromatography/principal component analysis/mechanism research分类
医药卫生引用本文复制引用
李彦荣,陈静,陈振东,颜鲁林,郭文龙,蒋宜伟..菊花-茶防治高血压合并高脂血症最佳配比筛选及生物信息学作用机制研究[J].甘肃中医药大学学报,2026,43(1):27-40,14.基金项目
国家自然科学基金地区项目(82360905) （82360905）
甘肃省自然基金项目(21JR1RA268) （21JR1RA268）
定西市科技计划项目(DX2021AZ04) （DX2021AZ04）
甘肃省教育厅高校教师创新基金项目(2023B-116). （2023B-116）
