国际老年医学杂志2026，Vol.47Issue(2)：151-155,5.DOI:10.3969/j.issn.1674-7593.2026.02.004
急性呼吸衰竭合并肺部感染老年患者血清单核细胞趋化蛋白-1、肽素的变化
Clinical significance of changes in serum monocyte chemoattractant protein-1 and copeptin levels in elderly patients with acute respiratory failure combined with pulmonary infection
摘要
Abstract
Objective To explore the clinical significance of changes in serum levels of monocyte chemoattractant protein-1(MCP-1)and copeptin in elderly patients with acute respiratory failure complicated by pulmonary infection.Methods A total of 212 elderly patients with acute respiratory failure were admitted to our hospital from January 2021 to January 2023 were selected as the study subjects.They were divided into an infected group(132 cases)and a non infected group(80 cases)based on whether pulmonary in-fection occurred.ELISA method was applied to detect the levels of serum MCP-1 and copeptin.Pulmonary function tester was used to measure forced vital capacity(FVC)and forced expiratory volume in one second(FEV1).Patients in the infection group were fol-lowed up for 1 year and divided into poor prognosis group(79 cases)and good prognosis group(53 cases)according to the prognosis.Pearson correlation was applied to analyze the relationship between serum MCP-1,copeptin levels and lung function indicators.ROC curve was applied to analyze the predictive value of serum MCP-1 and copeptin for poor prognosis in elderly patients with acute respira-tory failure complicated with pulmonary infection.Results The levels of MCP-1 and copeptin in the serum of the infected group were higher than those in the non infected group(P<0.05).The levels of FVC and FEV1 in the infected group were lower than those in the non infected group(P<0.05).The serum MCP-1 and copeptin levels in elderly patients with acute respiratory failure were negatively correlated with FVC and FEV1 levels(P<0.05).The levels of MCP-1 and copeptin in the serum of the poor prognosis group were higher than those of the good prognosis group(P<0.05).The AUC of predicting poor prognosis in elderly patients with acute respirato-ry failure complicated by pulmonary infection by the combination of serum MCP-1 and copeptin is higher than the predictive power of the two indicators alone(P<0.05).Conclusion MCP-1,copeptin levels are highly expressed in the serum of elderly patients with a-cute respiratory failure and pulmonary infection,and both are expected to become monitoring indicators for disease prognosis.关键词
急性呼吸衰竭/肺部感染/单核细胞趋化蛋白-1/肽素Key words
Acute respiratory failure/Pulmonary infection/Monocyte chemoattractant protein-1/Copeptin引用本文复制引用
公方娜,贾宏亮,单鸿伟..急性呼吸衰竭合并肺部感染老年患者血清单核细胞趋化蛋白-1、肽素的变化[J].国际老年医学杂志,2026,47(2):151-155,5.基金项目
内蒙古自治区自然科学基金项目(2023MS08018) （2023MS08018）
