广州中医药大学学报2026，Vol.43Issue(3)：580-588,9.DOI:10.13359/j.cnki.gzxbtcm.2026.03.005
补肾活血开窍方对急性缺血性脑卒中患者脑内神经递质及血管内皮功能的影响
Effects of Bushen Huoxue Kaiqiao Formula on Cerebral Neurotransmitters and Vascular Endothelial Function in Patients with Acute Ischemic Stroke
摘要
Abstract
Objective To investigate the efficacy of Bushen Huoxue Kaiqiao Formula in patients with acute ischemic stroke(AIS)and to observe its effects on cerebral neurotransmitters and vascular endothelial function.Methods A prospective study was conducted on 87 AIS patients with kidney deficiency and blood stasis syndrome treated at the Hengshui Seventh People's Hospital from January 2023 to January 2025.Patients were randomly divided into an observation group(44 cases)and a control group(43 cases)using a random number table.Both groups received basic treatments of maintaining water and electrolyte balance,protecting cerebral neuron,reducing cerebral edema,and low-flow oxygen therapy.Based on this,the control group received intravenous thrombolysis with alteplase,while the observation group received Bushen Huoxue Kaiqiao Formula in addition to the control group's treatment.The treatment course was 4 weeks,followed by an 8-week follow-up(total 12 weeks).Changes in traditional Chinese medicine(TCM)syndrome scores,National Institutes of Health Stroke Scale(NIHSS)scores,Modified Barthel Index(MBI)scores,cerebral neurotransmitter indicators,and vascular endothelial function indicators were observed before and after treatment.The clinical efficacy and medication safety of the two groups were evaluated.Results(1)Regarding efficacy,after 4 weeks of treatment,the total effective rate was 93.18%(41/44)in the observation group and 76.74%(33/43)in the control group.Intergroup comparisons showed that the overall efficacy(by Ridit test)and the total effective rate(by chi-square test)of the observation group were significantly superior to those of the control group(P＜0.05).(2)Regarding TCM syndromes,after 4,8,and 12 weeks of treatment,scores for hemiplegia,slurred speech,purple-dark tongue,and soreness and weakness of the waist and knees decreased in both groups compared to the previous observation time point(P＜0.05).The scores for these symptoms in the observation group were significantly lower than those in the control group at weeks 4,8,and 12(P＜0.05).(3)Regarding the degree of neurological deficit and life ability,after 4,8,and 12 weeks,NIHSS scores decreased in both groups compared to the previous time point(P＜0.05),while MBI scores increased(P＜0.05).The NIHSS scores in the observation group were significantly lower,and the MBI scores were significantly higher than those in the control group at weeks 4,8,and 12(P＜0.05).(4)Regarding cerebral neurotransmitters,after 4,8,and 12 weeks,serum levels of dopamine(DA)and 5-hydroxytryptamine(5-HT)decreased in both groups compared to the previous time point(P＜0.05),and the levels in the observation group were significantly lower than those in the control group(P＜0.05).(5)Regarding vascular endothelial function,after 4,8,and 12 weeks,serum endothelin-1(ET-1)levels decreased in both groups compared to the previous time point(P＜0.05),while nitric oxide(NO)levels increased(P＜0.05).The ET-1 levels in the observation group were significantly lower,and the NO levels were significantly higher than those in the control group at all time points(P＜0.05).(6)Regarding safety,the total incidence of adverse reactions was 6.82%(3/44)in the observation group and 9.30%(4/43)in the control group,with no statistically significant difference between the groups(P＞0.05).Conclusion Bushen Huoxue Kaiqiao Formula can effectively reduce the degree of neurological impairment,improve the ability of daily living,regulate the release of cerebral neurotransmitters such as 5-HT,and enhance vascular endothelial function in AIS patients with kidney deficiency and blood stasis syndrome,with no significant adverse reactions observed,demonstrating safety and efficacy.关键词
补肾活血开窍方/急性缺血性脑卒中/肾虚血瘀型/神经功能/生活能力/脑内神经递质/血管内皮功能Key words
Bushen Huoxue Kaiqiao Formula/acute ischemic stroke(AIS)/kidney deficiency and blood stasis type/neurological function/life ability/cerebral neurotransmitters/vascular endothelial function分类
医药卫生引用本文复制引用
刘海燕,宗兴燕,李伟,季辉..补肾活血开窍方对急性缺血性脑卒中患者脑内神经递质及血管内皮功能的影响[J].广州中医药大学学报,2026,43(3):580-588,9.基金项目
国家自然科学基金青年科学基金项目(编号:82302879) （编号:82302879）
