广州中医药大学学报2026，Vol.43Issue(3)：596-602,7.DOI:10.13359/j.cnki.gzxbtcm.2026.03.007
四君子汤合丹参饮加减方联合西药治疗舒张性心力衰竭气阴两虚夹瘀证的临床疗效
Clinical Efficacy of Modified Si Junzi Decoction Plus Danshen Decoction Integrated with Western Medicine in Treating Diastolic Heart Failure with Deficiency of Qi and Yin Interweaved with Blood Stasis Syndrome
摘要
Abstract
Objective To evaluate the clinical efficacy of Modified Si Junzi Decoction plus Danshen Decoction integrated with western medicine in treating patients with diastolic heart failure(DHF)of deficiency of qi and yin interweaved with blood stasis type,and to observe its impact on cardiac function.Methods A prospective randomized controlled trial design was conducted.Eighty DHF patients with deficiency of qi and yin interweaved with blood stasis syndrome admitted to the First Affiliated Hospital of Zhengzhou University from March 2024 to September 2024 were randomly divided into a control group and an observation group using a random number table,with 40 patients in each group.The control group received conventional western medicine treatment,while the observation group received Modified Si Junzi Decoction plus Danshen Decoction integrated with western medicine.The treatment duration for both groups was 6 weeks.Changes in traditional Chinese medicine(TCM)syndrome scores,cardiac function indicators,Minnesota Living with Heart Failure Questionnaire(MLHFQ)scores,and 6-minute walking distance(6MWD)were observed before and after treatment.The clinical efficacy was compared between the two groups,and clinical safety was evaluated.Results(1)Regarding efficacy,after 6 weeks of treatment,the total effective rate was 95.00%(38/40)in the observation group,significantly higher than 75.00%(30/40)in the control group.Intergroup comparison(by chi-square test)showed that the efficacy of the observation group was significantly superior to that of the control group(P＜0.05).(2)Regarding TCM syndrome scores,after treatment,scores for primary symptoms and secondary symptoms,and their total scores were decreased in both groups compared to those before treatment(P＜0.05),and the reductions were significantly greater in the observation group than in the control group(P＜0.01).(3)Regarding cardiac function indicators,after treatment,left ventricular end-diastolic diameter(LVEDD)and left ventricular end-systolic diameter(LVESD)were decreased in both groups compared to those before treatment(P＜0.05),while left ventricular ejection fraction(LVEF)was increased(P＜0.05).The improvements in all cardiac function indicators were significantly greater in the observation group than in the control group(P＜0.01).(4)Regarding quality of life and exercise tolerance,after 2,4,and 6 weeks of treatment,MLHFQ scores were decreased in both groups compared to the previous observation time point(P＜0.05),and 6MWD was increased(P＜0.05).The reductions in MLHFQ scores and the increases in 6MWD were significantly greater in the observation group than in the control group at weeks 2,4,and 6(P＜0.05).(5)Regarding safety,the total incidence of adverse reactions during treatment was 12.50%(5/40)in the observation group and 10.00%(4/40)in the control group,with no statistically significant difference between the groups(P＞0.05).Conclusion Modified Si Junzi Decoction plus Danshen Decoction integrated with western medicine can significantly alleviate clinical symptoms,improve cardiac function,enhance quality of life and exercise tolerance in DHF patients with deficiency of qi and yin interweaved with blood stasis syndrome,demonstrating notable efficacy and a favorable safety profile.关键词
舒张性心力衰竭/气阴两虚夹瘀证/四君子汤/丹参饮/心功能/生活质量/运动耐力/临床疗效Key words
diastolic heart failure(DHF)/deficiency of qi and yin interweaved with blood stasis/Si Junzi Decoction/Danshen Decoction/cardiac function/quality of life/exercise tolerance/clinical efficacy分类
医药卫生引用本文复制引用
王萍萍,王娟,李梅..四君子汤合丹参饮加减方联合西药治疗舒张性心力衰竭气阴两虚夹瘀证的临床疗效[J].广州中医药大学学报,2026,43(3):596-602,7.基金项目
河南省医学科技攻关计划(联合共建)项目(编号:LHGJ202101135) （联合共建）
