国际老年医学杂志2026，Vol.47Issue(2)：166-170,5.DOI:10.3969/j.issn.1674-7593.2026.02.007
白蛋白校正阴离子间隙对老年糖尿病酮症酸中毒患者预后的预测价值
Prognostic value of albumin corrected anion gap in elderly patients with diabetic ketoacidosis
摘要
Abstract
Objective To explore the predictive value of albumin corrected anion gap(ACAG)for the prognosis of elderly patients with diabetic ketoacidosis.Methods A total of 100 elderly patients with diabetic ketoacidosis admitted to Shengjing Hospital Affiliated to China Medical University from May 2022 to June 2024 were selected as the research subjects.The gender,age,body mass,height,duration of diabetes,type of diabetes,anion gap(AG),albumin(Alb),glycated hemoglobin(HbA1c),fasting blood glucose(FBG),blood ketone bodies(BK),urine ketone bodies(UK),arterial blood pH value,blood bicarbonate(HCO3-),and neutromids of 100 patients were collected The levels of cells(NEU)and lymphocytes(LYM),body mass index,the ACAG and neutrophil-to-lymphocyte ratio(NLR)were calculated.One hundred patients were followed up continuously for 28 days.According to the prognosis and survival status of the patients,they were divided into the survival group(71 cases)and the death group(29 cases).Through univariate and multivariate logistic regression analyses,the risk factors for poor prognosis in elderly patients with diabetic ketoacidosis were explored,and the predictive efficacy of ACAG for poor prognosis was evaluated using the receiver operating characteristic curve(ROC)curve.Results The results of univariate analysis showed that the levels of AG,ACAG,HbA1c,NEU and NLR in the death group were all higher than those in the survival group(P<0.05),and the levels of Alb and LYM were lower than those in the survival group(P<0.05)The results of multivariate logistic regression analysis showed that the levels of AG,ACAG,and HbA1c were risk factors for poor prognosis(P<0.05),while the level of Alb was a protective factor(P<0.05).ROC curve anal-ysis showed that the areas under the curve of AG,Alb,ACAG and HbA1c for predicting poor prognosis in elderly diabetic ketoacidosis patients were 0.757,0.765,0.814 and 0.771,respectively,ACAG had the highest predictive power.Conclusion ACAG has a high value in predicting the prognosis of elderly patients with diabetic ketoacidosis and is recommended for clinical promotion and appli-cation.关键词
白蛋白校正阴离子间隙/糖尿病/酮症酸中毒/预后/预测价值Key words
Albumin corrected anion gap/Diabetic/Ketoacidosis/Prognosis/Predictive value引用本文复制引用
王思萌,李红瑶,王冬梅,姜艳..白蛋白校正阴离子间隙对老年糖尿病酮症酸中毒患者预后的预测价值[J].国际老年医学杂志,2026,47(2):166-170,5.基金项目
国家自然科学基金资助项目(81072182) （81072182）
