基础医学与临床2026，Vol.46Issue(3)：367-373,7.DOI:10.16352/j.issn.1001-6325.2026.03.0367
大株红景天注射液对非酒精性脂肪性肝病模型大鼠的治疗作用
Therapeutic effects of Sofren injection on non-alcoholic fatty liver disease in rat models
摘要
Abstract
Objective To investigate the hepato-protective effects of Sorfren injection on rat liver injury resulted from non-alcoholic fatty liver disease(NAFLD).Methods Rats were randomly divided into control,NAFLD model and Sofren-treated groups.The Sofren-treated groups was developed by feeding a high-fat diet(HFD)for 8 weeks.Subsequently,the Sofren-treated group received tail vein injections of Sofren solution(0.4 mL/100 g)for 8 weeks.Serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST)levels were measured using an auto-matic biochemical analyzer.Tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),IL-6 and malondialdehyde(MDA)were quantified by enzyme-linkedimmunosorbent assay(ELISA).Superoxide dismutase(SOD)activity was assessed by chromogenic method.Histopathological evaluations were performed by Hematoxylin-Eosin(HE)and Prussian blue staining.Immunohistochemistry and Western blot were applied to analyze the expression of glutathione peroxidase 4(GPX4),nuclear factor erythroid 2-related factor 2(Nrf2),heme oxygenase-1(HO-1),transferrin receptor 1(TFR1)and ferritin heavy chain 1(FTH1).Results Compared with control group,the model group exhibited significant elevation of serum ALT,AST,MDA,and inflammatory mediators(TNF-α,IL-1β,IL-6),reduction of SOD activity,increased hepatic iron deposition,down-regulated Nrf2,HO-1,and GPX4 expression,and up-regulated level of TFR1 and FTH1(P＜0.05).Treatment with Sofren injection markedly reversed these pathological alterations(P＜0.05).Conclusions Sofren injection may alleviate liver injury in NAFLD rats.关键词
大株红景天注射液/非酒精性脂肪性肝病/核因子E2相关因子2/血红素加氧酶-1/铁死亡Key words
Sofren injection/non-alcoholic fatty liver disease/nuclear factor erythroid 2-related factor 2/heme oxygenase-1/ferroptosis分类
医药卫生引用本文复制引用
徐霞,王富兵,赵培培,范辉,李欣,张谷,顾新红..大株红景天注射液对非酒精性脂肪性肝病模型大鼠的治疗作用[J].基础医学与临床,2026,46(3):367-373,7.基金项目
南通市基础科学研究和社会民生科技计划项目(MSZ2022135) （MSZ2022135）
