江苏农业学报2026，Vol.42Issue(2)：373-381,9.DOI:10.3969/j.issn.1000-4440.2026.02.016
地衣芽孢杆菌JH41C的抑菌特性及全基因组测序分析
Antibacterial characteristics and genome sequencing analysis of Bacillus li-cheniformis JH41C
摘要
Abstract
This study presents a comprehensive analysis of the antimicrobial characteristics and whole genome of Ba-cillus licheniformis strain JH41C.The results of in vitro antimicrobial tests demonstrated that JH41C strain exhibited signifi-cant inhibitory effects against Clostridium perfringens and Staphylococcus aureus.High-performance liquid chromatography analysis confirmed that the JH41C strain produced bacitracin.The strain also secreted amylase and cellulase.The 4 450 351 bp genome(G+C content 45.94%)contained 4 387 predicted protein-coding genes,including numerous metabolic genes and biosynthetic gene clusters for antibiotics such as penicillins and cephalosporins.Twelve secondary-metabolite clusters were identified,four of which correspond to non-ribosomal peptide synthetase pathways.These findings highlight the poten-tial of JH41C for pathogen control,enhanced feed utilization,and antibiotic substitution,offering a theoretical basis for next-generation microecological agents.关键词
地衣芽孢杆菌/抑菌特性/全基因组测序/次级代谢产物/杆菌肽/纤维素酶Key words
Bacillus licheniformis/antibacterial properties/whole genome sequencing/secondary metabolites/bacitracin/cellulase分类
农业科技引用本文复制引用
胡修忠,刘爽,向敏,李筱雯,余婕,刘辰晖,钟朱夏,王定发,程蕾..地衣芽孢杆菌JH41C的抑菌特性及全基因组测序分析[J].江苏农业学报,2026,42(2):373-381,9.基金项目
湖北省重点研发计划项目(2023DJC145) （2023DJC145）
