实用心电与临床诊疗2026，Vol.35Issue(1)：72-77,封3,7.DOI:10.13308/j.issn.2097-5716.xd20250305
基于PhysioNet QT数据库的QT间期校正公式效能评估与个体化校正启示
Efficacy assessment of QT interval correction formulas and implications for individualized correction:a study based on the PhysioNet QT database
崔燕萍 1徐春红 1沈丽萍1
作者信息
- 1. 201700 上海,复旦大学附属中山医院青浦分院心电图室
- 折叠
摘要
Abstract
Objective Based on repeatedly measured data from a public electrocardiogram(ECG)database,to compare the correction efficacy of four QT interval correction formulas—Bazett,Fridericia,Framingham,and Hodges across different heart rate levels,and to explore the necessity of individualized correction.Methods A total of 2 151 valid heartbeats from 75 subjects were selected from the PhysioNet QT database,and stratified by heart rate(<60 beats/min,60-100 beats/min and>100 beats/min).The corrected QT interval(QTc)was calculated using the above four formulas,and the correction efficacy of each formula within different heart rate ranges was analyzed.Results The Fridericia(ρ=0.000 3,P=0.989)and Framingham(ρ=0.002 7,P=0.899)formula-corrected QTc showed the weakest residual correlation with heart rate.Intergroup analysis revealed no statistically significant differences in QTc after correction by using the Framingham formula among the three groups(P=0.278).The Fridericia formula showed a borderline significant difference(P=0.045).The Bazett formula exhibited significant overcorrection in the high heart rate group,with a QTc prolongation rate as high as 63.9%(QTc>450 ms)and a strong residual positive correlation with heart rate(ρ=0.357,P<0.01).The Hodges formula performed well within normal heart rate range but exhibited correction bias beyond this range.Linear mixed-effects model analysis indicated significant interindividual variability in QTc after correction with all formulas.Conclusion The Fridericia and Framingham formulas demonstrated the lowest heart rate dependence.They could be recommended as the first clinical choice.Use of the Bazett formula should be avoided when heart rate exceeds 100 beats/min.Population-based formulas have inherent limitations.Therefore,individualized QTc correction methods are needed to improve the accuracy of QT interval assessment.关键词
QT间期/校正的QT间期/Fridericia公式/Framingham公式/个体化QTc校正Key words
QT interval/corrected QT interval/Fridericia formula/Framingham formula/individualized QTc correction分类
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崔燕萍,徐春红,沈丽萍..基于PhysioNet QT数据库的QT间期校正公式效能评估与个体化校正启示[J].实用心电与临床诊疗,2026,35(1):72-77,封3,7.
