分子影像学杂志2026，Vol.49Issue(2)：141-146,6.DOI:10.12122/j.issn.1674-4500.2026.02.01
靶向大麻素2型受体PET探针18F-JR-1002在胰腺导管腺癌分子成像中的应用
Molecular imaging of pancreatic cancer with a cannabinoid type 2 receptor targeted PET probe
摘要
Abstract
Objective To develop a novel PET probe(18F-JR-1002)targeting the cannabinoid type 2 receptor(CB2R)for the molecular imaging diagnosis of pancreatic ductal adenocarcinoma(PDAC).Methods 18F-JR-1002 was designed and synthesized based on a CB2R inverse agonist structure.Radiolabeling was performed using an automated synthesizer(OnePlatform V3.1s),and its radiochemical yield,molar activity,and in vitro stability were determined.An orthotopic PDAC mouse model was established using PANC-2-luc cells.MicroPET/CT imaging was utilized to assess probe uptake in tumor tissues,which was compared with that in normal mice.Results The radiochemical yield of ¹⁸F-JR-1002 was 34.7%±8.1%,with a molar activity of 264.5±41.2 GBq/µmol.It demonstrated excellent in vitro stability(>95%over 3 h).MicroPET imaging revealed significantly higher probe uptake in the pancreatic region of PDAC mice compared to the normal group(P=3.34×10-9),indicating the probe's specific recognition of CB2R,which is highly expressed in PDAC tissues.Conclusion This study successfully developed a highly stable and affine CB2R-targeted PET probe that specifically identifies PDAC,providing a new molecular imaging tool for early diagnosis and treatment efficacy evaluation.关键词
大麻素2型受体/正电子发射断层成像/放射性示踪剂/胰腺癌/诊断Key words
cannabinoid receptor type Ⅱ/positron emission tomography/radioactive tracer/pancreatic cancer/diagnosis引用本文复制引用
金灿,曹星海,陈俊威,谢玲华,毛迪龙,和庆钢..靶向大麻素2型受体PET探针18F-JR-1002在胰腺导管腺癌分子成像中的应用[J].分子影像学杂志,2026,49(2):141-146,6.基金项目
国家自然科学基金重大科研仪器研制项目(32027802) （32027802）
科技部重点研发计划课题(2021YFA1101702) （2021YFA1101702）
浙江省"领雁"计划项目(2022C03071、2024C03100)Supported by the National Natural Science Foundation of China Major Research Instrument Development Project(32027802) （2022C03071、2024C03100）
