分子影像学杂志2026，Vol.49Issue(2)：147-153,7.DOI:10.12122/j.issn.1674-4500.2026.02.02
阿尔茨海默症患者灰质萎缩与认知评分具有相关性:基于体素的形态学测量方法
Gray matter atrophy correlates with cognitive scores in Alzheimer's disease patients:a voxel-based morphometry study
摘要
Abstract
Objective To investigate regional alterations in gray matter volume(GMV)among patients with Alzheimer's disease(AD)using voxel-based morphometry(VBM),and to explore the association between these structural changes and clinical cognitive assessment scores.Methods A total of 61 participants were selected from the Alzheimer's Disease Neuroimaging Initiative database.Based on predefined inclusion and exclusion criteria,subjects were categorized into two groups:32 individuals diagnosed with AD(AD group)and 29 cognitively healthy controls(HC group).VBM was applied to calculate and compare GMV across groups.Significant intergroup differences in brain regions were identified using a dual-threshold statistical approach involving voxel-level family-wise error(FWE)correction and cluster-level false discovery rate(FDR)correction(P<0.05).Brain regions exhibiting significant atrophy were further analyzed for correlations with clinical scale scores,specifically,the Mini-Mental State Examination(MMSE)and Clinical Dementia Rating(CDR),using Pearson correlation analysis.Results Total GMV was significantly reduced in the AD group compared to the HC group(P<0.05).Regional analyses revealed three clusters showing significant GMV reductions in AD patients,with peak coordinates located in the right superior temporal pole,left amygdala,and left middle cingulate gyrus.As anticipated,the AD group performed significantly worse on both MMSE and CDR assessments(P<0.001).Correlation analyses demonstrated that,within the AD group,higher MMSE scores were positively associated with GMV in all three affected regions(P<0.05).In contrast,CDR scores showed negative correlations with GMV in the right superior temporal pole and left amygdala(P<0.05).Conclusion VBM analysis confirms characteristic patterns of gray matter atrophy in AD,predominantly affecting the temporal pole,amygdala,and cingulate cortex.The significant associations between regional GMV loss and cognitive performance suggest that such structural changes may represent key neuroanatomical substrates underlying the clinical symptoms and pathophysiological progression of AD.关键词
阿尔茨海默症/基于体素的形态学测量/灰质体积Key words
Alzheimer's disease/voxel-based morphometry/gray matter volume引用本文复制引用
张佳云,樊丽华,田欣,郑运松,周锋..阿尔茨海默症患者灰质萎缩与认知评分具有相关性:基于体素的形态学测量方法[J].分子影像学杂志,2026,49(2):147-153,7.基金项目
国家自然科学基金面上项目(81873387) （81873387）
全国中医药创新骨干人才项目([2019]128号) （[2019]128号）
第五批陕西省优秀中医临床人才研修项目([2025]6号) （[2025]6号）
陕西省中管局中医药科技创新计划项目(2025-CXTD-12) （2025-CXTD-12）
陕西中医药大学科技创新团队项目(2023-CXTD-02)Supported by National Natural Science Foundation of China(81873387). （2023-CXTD-02）
