菌物学报2026，Vol.45Issue(3)：32-42,11.DOI:10.13346/j.mycosystema.250234
非白念珠菌所致外阴阴道念珠菌病菌种多样性及抗真菌药敏特点
Species diversity and antifungal susceptibility of non-albicans yeast causing vulvovaginal candidiasis
摘要
Abstract
In total,310 isolates of non-albicans yeast(NAY)recovered from vulvovaginal candidiasis(VVC)patients were collected and identified at species level,and antifungal susceptibility of the isolates was determined.Literature relating to non-albicans yeast(NAY)species distribution in recent 10 years was searched and 7 publications were included in this study.Data of the literature together with the data of this study indicated that spectrum of NAY causing VVC shifted significantly.Nakaseomyces glabratus is the predominant species among NAY,responsible for 41.34%-80.43%of vaginal NAY infection.The other NAY species revealed characteristics of regional distribution.For example,Candida parapsilosis(Portugal 23.74%,UK 20.38%)and Pichia kudriavzevii(Serbia 22%,Greece 11.30%)dominated higher ratio in Europe,while C.tropicalis showed higher ratio in China and Greece(both 7.40%).Rare yeast mainly consist of species of saccharomycotina.They are diverse and distinctly different in distribution pattern between China and Europe.Fluconazole is still optimal oral treatment option in China,and clotrimazole and amphotericin B could be precedent choices as topical drugs for treating VVC caused by NAY.Increase of rare yeast would be a challenge for clinical treatment of VVC.Correct identification at species level and determination of susceptibility to antifungals are necessary.关键词
外阴阴道念珠菌病/非白念酵母菌/菌种分布/抗真菌活性Key words
vulvovaginal candidiasis/non-albicans yeast/species distribution/antifungal activity引用本文复制引用
孙艳霞,张璐,阿里木ꞏ艾山,胡丹阳,邓淑文,刘芳..非白念珠菌所致外阴阴道念珠菌病菌种多样性及抗真菌药敏特点[J].菌物学报,2026,45(3):32-42,11.基金项目
资助项目:苏州市科技计划项目(SKY2022037) （SKY2022037）
苏州高新区人民医院科学创新基金项目(SGY2023B02,SGY2025H01,SGY2025H02) （SGY2023B02,SGY2025H01,SGY2025H02）
江苏省高端医疗器械技术创新中心项目(BM2022012) This work was supported by the grant from Suzhou Bureau of Science and Technology(SKY2022037),the People's Hospital of SND Science Development Grant(SGY2023B02,SGY2025H01,SGY2025H02),and the Jiangsu High-end Medical Device Technology Innovation Center(BM2022012). （BM2022012）
