临床与实验病理学杂志2026，Vol.42Issue(2)：171-176,6.DOI:10.13315/j.cnki.cjcep.2026.02.005
子宫内膜异位症中CMTM6、PD-L1的表达及意义
Expression of CMTM6 and PD-L1 in endometriosis and their significance
摘要
Abstract
Objecitve To investigate the expression of CMTM6 and PD-L1 in endometriosis(EM)and their sig-nificance.Methods Ovarian ectopic endometrial tissues obtained by laparoscopic resection and eutopic endometrial tissues collected by curettage were obtained from 50 patients with EM(experimental group).Eutopic endometrial tis-sues from 30 non-EM patients(control group)were collected by curettage.The expression levels of CMTM6 and PD-L1 were detected by immunohistochemical method.Clinicopathological data of the experimental group,including age,body mass index(BMI),lesion size,serum CA-125 concentration,and rAFS score,were collected.The correlations between the expression of CMTM6 and PD-L1 and the above pathological parameters were analyzed by Spearman corre-lation coefficient.Human endometriotic epithelial cell line 12Z was cultured,western blot and co-immunoprecipitation were used to detect the expression levels and interaction of CMTM6 and PD-L1.Results CMTM6 and PD-L1 were highly expressed in EM patients,and their expression levels in ectopic and eutopic endome-tria of EM patients were higher than those in eutopic endometria of non-EM patients(P<0.05).The positive expres-sions of CMTM6 and PD-L1 were co-localizeed in the plasma membrane of epithelial cells in both ectopic and eutopic endometria,and their expression levels showed a positive correlation(P<0.05).Patient age,BMI,lesion size,serum CA-125 concentration,and rAFS score were positively correlated with CMTM6 and PD-L1 expression(P<0.01).CMTM6 and PD-L1 proteins were highly expressed in 12Z cells,and they could bind to each other.Conclu-sion CMTM6 and PD-L1 are highly expressed in EM patients,and the expression levels of CMTM6 and PD-L1 are correlated with the severity of EM lesions.CMTM6 and PD-L1 can interact in EM to jointly participate in the occur-rence and development of EM.CMTM6 and PD-L1 may be potential biological markers of EM,providing new targets for clinical diagnosis and treatment of EM.关键词
子宫内膜异位症/CMTM6/PD-L1/免疫蛋白共沉淀Key words
endometriosis/CMTM6/PD-L1/co-immunoprecipitation分类
医药卫生引用本文复制引用
杜薇,王小红,孔令英,王丽,程世越,田启华..子宫内膜异位症中CMTM6、PD-L1的表达及意义[J].临床与实验病理学杂志,2026,42(2):171-176,6.基金项目
福建省自然科学基金面上项目(2024J01755) General Program of Fujian Provincial Natural Science Foundation(2024J01755) （2024J01755）
