摘要
Abstract
Objective To investigate the relationship between molecular typing and clinicopathological charac-teristics of endometrial carcinoma(EC),aiming to provide a basis for individualized treatment.Methods Clinical data of 114 EC cases were collected,and gene analysis was performed by NGS.According to the WHO(2020)classi-fication of female genital tract tumors,the molecular typing was classified into 4 subtypes:POLE ultramutated(POLE mut),mismatch repair deficiency(MMRd),no specific molecular profile(NSMP),and p53 abnormal(p53abn).Statistical analysis was performed to assess the correlation between different molecular subtypes and clinicopathologi-cal characteristics.Results Among the 114 EC patients,16(14.0%)were POLE mut,37(32.5%)were MMRd,37(32.5%)were NSMP,and 24(21.0%)were p53abn.For different pathological types,low-grade(G1+G2)EC was most commonly classified as NSMP and least as p53abn,with high-frequency gene mutations in PTEN,PIK3CA,and CTNNB1.High-grade(G3)EC and clear cell carcinoma were predominantly classified as MMRd and p53abn,ex-hibiting a higher mutation frequency of TP53.Clear cell carcinoma showed a broader mutation spectrum,including MSH6,POLE,and PTEN.Serous carcinoma and carcinosarcoma were all classified as p53abn.There were statisti-cally significant differences in histological grade(P<0.001),cervical stromal invasion(P=0.009),FIGO stage(P=0.031),and pathological type(P<0.001)among different subtypes of EC.Univariate Logistic regression analysis in-dicated that NSMP was positively correlated with low histological grade(OR=0.08,95%CI:0.02-0.36),early FIGO stage(OR=0.20,95%CI:0.04-0.93),and pathological type of endometrioid carcinoma(OR=14.4,95%CI:1.86-111.6);whereas p53abn was positively correlated with high histological grade(OR=10.4,95%CI:3.74-29.1),cer-vical stromal invasion(OR=11.6,95%CI:2.10-64.2),and pathological type of non-endometrioid carcinoma(OR=0.14,95%CI:0.05-0.39)(P<0.05).Multivariate Logistic regression model showed that p53abn was independently positively correlated with high histological grade(OR=5.61,95%CI:1.19-26.5)and cervical stromal invasion(OR=8.25,95%CI:1.18-57.5),indicating its malignant characteristics in EC progression.Conclusion The molecular typing of EC is significantly related to clinicopathological characteristics,and comprehensive evaluation is helpful for more accurate pathological diagnosis and clinical treatment.关键词
子宫内膜癌/分子分型/临床病理特征/相关性Key words
endometrial carcinoma/molecular typing/clinicopathological characteristics/relationship分类
医药卫生
