兰州大学学报（医学版）2026，Vol.52Issue(1)：1-7,7.DOI:10.13885/j.issn.2097-681X.T20260002
阿尔茨海默病外周与中枢神经免疫交互机制及干预策略
Peripheral and central neuroimmune crosstalk in Alzheimer's disease:mechanisms and therapeutic strategies
摘要
Abstract
Alzheimer's disease(AD)involves complex pathogenic mechanisms and its pathological process implicates an extensive participation of the systemic immune system.This review discussed the core mecha-nisms of peripheral and central neuroimmune crosstalk in AD progression by highlighting how blood-brain barrier disruption and meningeal lymphatic dysfunction mediated the infiltration of peripheral immune cells into the brain,where they established a pro-inflammatory positive feedback loop with microglia.Furthermore,the regulatory roles of key molecules,including apolipoprotein E4,β2-microglobulin and triggering receptor expressed on myeloid cells 2,in neuroimmune communication were also analyzed.Finally,novel intervention strategies targeting the neuroimmune axis,such as immune checkpoint blockade and regulatory T cell adop-tive transfer,were discussed to provide a theoretical basis for clinical precision treatment in AD.关键词
阿尔茨海默病/神经免疫交互/血脑屏障/外周免疫细胞/免疫治疗/靶向神经免疫轴Key words
Alzheimer's disease/neuroimmune crosstalk/blood-brain barrier/peripheral immune cell/immu-notherapy/targeting the neuro-immune axis分类
医药卫生引用本文复制引用
张硕,郑秋阳,王鑫..阿尔茨海默病外周与中枢神经免疫交互机制及干预策略[J].兰州大学学报（医学版）,2026,52(1):1-7,7.基金项目
国家自然科学基金卓越研究群体资助项目B类(82588301) （82588301）
国家自然科学基金杰出青年基金资助项目(82325018) （82325018）
国家自然科学基金区域联合基金重点资助项目(U25A2055) （U25A2055）
国家自然科学基金面上基金资助项目(82271451) （82271451）
