兰州大学学报（医学版）2026，Vol.52Issue(1)：15-22,8.DOI:10.13885/j.issn.2097-681X.T20260009
神经-肿瘤互作:生物学机制研究与临床转化前景
Neuro-cancer interaction:biological mechanisms and clinical translational perspectives
摘要
Abstract
The nervous system participates in tumor initiation,progression,and therapeutic responses through various mechanisms,driving the rapid development of cancer neuroscience as an emerging field.The central focus of this area shifted from whether nerves influence tumors to the specific levels at which neural regula-tion operates.From a holistic brain-body interaction perspective,this review systematically examined recent advances in neural-tumor interactions,with emphasis on three main regulatory modes:local structural interac-tions,functional neural circuit regulation,and indirect neural modulation of immunity and metabolism,along with their research foundations and mechanistic characteristics.Furthermore,it evaluated potential therapeutic strategies targeting neural-tumor interactions and their translational prospects.This review underscored that clarifying the systemic roles of distinct neural regulatory modes in tumor progression is essential for guiding the rational development and clinical translation of this field.关键词
肿瘤/神经系统/肿瘤微环境/神经-肿瘤互作/神经环路/肿瘤治疗/临床转化Key words
tumor/nervous system/tumor microenvironment/neural-tumor interactions/neural circuits/tu-mor therapy/clinical translation分类
医药卫生引用本文复制引用
武健壮,张维一,孙皓宇,闫超..神经-肿瘤互作:生物学机制研究与临床转化前景[J].兰州大学学报（医学版）,2026,52(1):15-22,8.基金项目
国家自然科学青年科学基金资助项目(32525029) （32525029）
中国博士后科学基金面上资助项目(2025M782074) （2025M782074）
江苏省卓越博士后计划资助项目(2025ZB117) （2025ZB117）
南京鼓楼医院国家自然科学基金青年培育项目(2025-JCYJ-QP-077) （2025-JCYJ-QP-077）
