西南医科大学学报2026，Vol.49Issue(2)：127-133,7.DOI:10.3969/j.issn.2096-3351.2026.02.001
金属暴露与肠道微生物群的相互作用及健康效应
Interaction between Metal Exposure and Gut Microbiota and Health Effects
摘要
Abstract
This review systematically summarizes the complex interactions between metal exposure and the gut microbiota and their consequential impacts on host health.Metal exposure alters gut microbial composition in a dose-dependent manner,suppressing beneficial bacteria,promoting potential pathogens,and altering microbial diversity and ecological networks.In turn,the gut microbiota modulates metal absorption,transformation,distribution,and excretion,thereby critically influencing metal bioavailability and toxic-ity,and playing pivotal roles in both detoxification and toxicity enhancement.These interactions constitute the"metal-microbiota-host"axis,whose dynamic equilibrium profoundly shapes the ultimate health outcomes of metal exposure.Current research focuses on probiotic interventions to restore microbial balance,while future studies should employ multi-omics approaches to elucidate underlying mechanisms,thereby informing novel strategies for microbiotabased interventions and mitigation of metal-related health risks.关键词
金属暴露/肠道微生物群/微生物-宿主相互作用Key words
Metal exposure/Gut microbiome/Microbiota-host interactions分类
医药卫生引用本文复制引用
魏长黎,刘雨琦,高霞,邓翰林,邹镇,许商成,陈承志..金属暴露与肠道微生物群的相互作用及健康效应[J].西南医科大学学报,2026,49(2):127-133,7.基金项目
国家重点研发计划项目(2025YFC2511700) （2025YFC2511700）
重庆市自然科学基金创新联合发展基金(CSTB2023NSCQ-LZX0059) （CSTB2023NSCQ-LZX0059）
