临床与实验病理学杂志2026，Vol.42Issue(2)：199-205,211,8.DOI:10.13315/j.cnki.cjcep.2026.02.009
Tiam1差异表达对卵巢癌预后及其生物学功能的影响
Impact of differential expression of Tiam1 on prognosis and biological functions of ovarian cancer
摘要
Abstract
Objective To investigate the expression levels and clinical value of Tiam1 in ovarian cancer,and to unveil its effects on the biological processes of ovarian cancer cells.Methods Databases such as cBioPortal and SangerBox were used to analyze the mRNA alterations and expression levels of Tiam1 across various tumor types.Bio-informatics analyses were conducted to investigate Tiam1 expression in ovarian cancer tissues and its correlation with patient prognosis.The Linkedomics database was utilized to identify Tiam1-regulated downstream genes and associ-ated signaling pathways in ovarian cancer.Immunohistochemical SP staining was performed to detect the protein ex-pression of Tiam1 in ovarian tissues.Stable ovarian cancer cell lines with differential Tiam1 expression were con-structed to assess the effects of Tiam1 on cell proliferation,migration,and epithelial-mesenchymal transition(EMT)process.Results Multi-database analyses revealed that Tiam1 mRNA expression levels were significantly higher in various tumor tissues including ovarian cancer than in normal tissues(P<0.05).Additionally,high Tiam1 expression was closely associated with the increased malignancy,poor prognosis,and altered chemotherapeutic drug sensitivity in ovarian cancer patients(P<0.05).Immunohistochemical staining further confirmed that Tiam1 protein showed posi-tive expression in ovarian cancer tissues and negative expression in benign ovarian lesions(P<0.05).Both enrich-ment analysis based on the Linkedomics database and in vitro cell function assays consistently demonstrated that Tiam1 expression was significantly associated with enhanced cell migration and promoted the EMT process in ovarian cancer cells.Conclusion High Tiam1 expression predicts poor prognosis and increased sensitivity to chemotherapeutic drugs.Additionally,Tiam1 promotes cancer cell proliferation,migration,and EMT process in ovarian cancer cells,making it a promising novel biomarker for targeted therapy in ovarian cancer patients.关键词
卵巢癌/Tiam1/预后评估/药物敏感性/增殖/迁移/EMTKey words
ovarian cancer/Tiam1/prognostic evaluation/drug sensitivity/proliferation/migration/EMT分类
医药卫生引用本文复制引用
朱泾嫣,窦珺童,杨洋,权海燕,林贞花..Tiam1差异表达对卵巢癌预后及其生物学功能的影响[J].临床与实验病理学杂志,2026,42(2):199-205,211,8.基金项目
吉林省科技厅中央引导地方科技发展资金(202002021JC) Central Guidance on Local Science and Technology Development Fund of Jilin Province(202002021JC) （202002021JC）
