兰州大学学报（医学版）2026，Vol.52Issue(1)：23-32,10.DOI:10.13885/j.issn.2097-681X.T20260004
劫持稳态:肿瘤恶液质中的脑-体神经回路与治疗机遇
Hijacking homeostasis:brain-body neural circuits in cancer cachexia and therapeutic opportunities
摘要
Abstract
Cancer cachexia is a multifactorial syndrome characterized by progressive skeletal muscle wasting(with or without loss of adipose tissue)that cannot be fully reversed by conventional nutritional support.Traditionally viewed as a peripheral disorder driven by tumor-induced systemic inflammation and metabolic dysregulation,emerging evidence now highlights the central nervous system,particularly the hypothalamus,as a pivotal target in tumor-mediated systemic disruption.This review proposed a"homeostatic hijack-ing"model,systematically elaborating on how tumors release signaling molecules—such as exosomes,inflam-matory cytokines and metabolites—to hijack brain-body neural circuits,thereby reprogramming energy alloca-tion and feeding behavior,and ultimately driving the vicious cycle of cachexia.We analyzed the neuroimmun-emetabolic mechanisms underlying cachexia from two interconnected dimensions:"brain-to-body"(central command dysregulation)and"body-to-brain"(peripheral signal feedback).Furthermore,we prospectively discussed novel therapeutic strategies targeting the brain-body interface,offering a refreshed framework for intervening in this intractable syndrome.关键词
肿瘤恶液质/脑-体互作/神经回路/下丘脑/稳态劫持/治疗靶点Key words
cancer cachexia/brain-body interaction/neural circuits/hypothalamus/homeostatic hijacking/therapeutic targets分类
医药卫生引用本文复制引用
王勇飞,齐冬扬,袁文臻,金卫林..劫持稳态:肿瘤恶液质中的脑-体神经回路与治疗机遇[J].兰州大学学报（医学版）,2026,52(1):23-32,10.基金项目
兰州大学第一医院高层次人才引进基金 （）
